Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D286644-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $107.90 | |
D286644-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $173.90 | |
D286644-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $347.90 | |
D286644-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $641.90 | |
D286644-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,142.90 |
Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
Synonyms | 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole;Dooku1;2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazol |
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Specifications & Purity | ≥98%(HPLC) |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of Piezo1 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 2-[(2,6-dichlorophenyl)methylsulfanyl]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole |
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INCHI | InChI=1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2 |
InChi Key | MNPOBXLPCWFONX-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C(C(=C1)Cl)CSC2=NN=C(O2)C3=CC=CN3)Cl |
PubChem CID | 137321150 |
Molecular Weight | 326.2 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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C2222154 | Certificate of Analysis | Feb 22, 2022 | D286644 |
C2222598 | Certificate of Analysis | Feb 22, 2022 | D286644 |
C2222603 | Certificate of Analysis | Feb 22, 2022 | D286644 |
C2222606 | Certificate of Analysis | Feb 22, 2022 | D286644 |
C2222608 | Certificate of Analysis | Feb 22, 2022 | D286644 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 32.62, Max Conc. mM: 100 |
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Sensitivity | Moisture sensitive. |
1. Evans EL, Cuthbertson K, Endesh N, Rode B, Blythe NM, Hyman AJ, Hall SJ, Gaunt HJ, Ludlow MJ, Foster R et al.. (2018) Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.. Br J Pharmacol, 175 (10): (1744-1759). [PMID:29498036] |