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Dooku 1 - ≥98%(HPLC), high purity , CAS No.2253744-54-4, Inhibitor of Piezo1

  • Moligand™
  • ≥98%(HPLC)
Item Number
D286644
Grouped product items
SKUSizeAvailabilityPrice Qty
D286644-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$107.90
D286644-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$173.90
D286644-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$347.90
D286644-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$641.90
D286644-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,142.90

Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity

View related series
Piezo1 Inhibitor

Basic Description

Synonyms2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole;Dooku1;2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazol
Specifications & Purity≥98%(HPLC)
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Piezo1

Associated Targets

PIEZO1 Tchem Piezo-type mechanosensitive ion channel component 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[(2,6-dichlorophenyl)methylsulfanyl]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
INCHI InChI=1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2
InChi Key MNPOBXLPCWFONX-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C(C(=C1)Cl)CSC2=NN=C(O2)C3=CC=CN3)Cl
PubChem CID 137321150
Molecular Weight 326.2

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
C2222154Certificate of AnalysisFeb 22, 2022 D286644
C2222598Certificate of AnalysisFeb 22, 2022 D286644
C2222603Certificate of AnalysisFeb 22, 2022 D286644
C2222606Certificate of AnalysisFeb 22, 2022 D286644
C2222608Certificate of AnalysisFeb 22, 2022 D286644

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 32.62, Max Conc. mM: 100
SensitivityMoisture sensitive.

Related Documents

References

1. Evans EL, Cuthbertson K, Endesh N, Rode B, Blythe NM, Hyman AJ, Hall SJ, Gaunt HJ, Ludlow MJ, Foster R et al..  (2018)  Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation..  Br J Pharmacol,  175  (10): (1744-1759).  [PMID:29498036]

Solution Calculators