Doxycycline hyclate - analytical standard, high purity , CAS No.24390-14-5

Item Number
D111942
Grouped product items
SKUSizeAvailabilityPrice Qty
D111942-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$169.90
D111942-500mg
500mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$755.90
D111942-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,353.90
D111942-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$5,871.90

Basic Description

SynonymsDoxycycline hydrochloride hydrate (JP17) | Periostat | AKOS025402170 | DOXYCYCLINE HYCLATE [VANDF] | DOXYCYCLINE HYCLATE [ORANGE BOOK] | Doxycycline hyclate 100 microg/mL in Acetonitrile | trans-1,3-Pentadiene, analytical standard | Doxycycline hyclate (i
Specifications & Purityanalytical standard
Storage TempStore at 2-8°C
Shipped InWet ice
Gradeanalytical standard

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride
INCHI InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
InChi Key UHHHTIKWXBRCLT-VDBOFHIQSA-N
Canonical SMILES CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
Isomeric SMILES CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
WGK Germany 3
RTECS QI8925000
Alternate CAS 10592-13-9
PubChem CID 54686183
Molecular Weight 512.94
Beilstein 5702728

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
D1926065Certificate of AnalysisNov 11, 2022 D111942
D2411051Certificate of AnalysisAug 26, 2022 D111942
H2223141Certificate of AnalysisAug 26, 2022 D111942
H2223142Certificate of AnalysisAug 26, 2022 D111942
H2223107Certificate of AnalysisAug 26, 2022 D111942
H2223143Certificate of AnalysisAug 26, 2022 D111942

Chemical and Physical Properties

Specific Rotation[α]-104° (C=1,0.01mol/L HCl(MeOH))

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H411:Toxic to aquatic life with long lasting effects

H302:Harmful if swallowed

H400:Very toxic to aquatic life

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS QI8925000
Merck Index 3440

Related Documents

Citations of This Product

1. Guanhua Liu, Luting Wang, Anan Zhao, Leijie Guo, Liya Zhou, Ying He, Li Ma, Yunting Liu, Jing Gao, Yanjun Jiang.  (2023)  Biocatalytic membranes with crosslinked enzyme aggregates for micropollutant removal.  CHEMICAL ENGINEERING JOURNAL,    (147635).  [PMID:23145173] [10.1016/j.cej.2023.147635]
2. Fuhua Wei, Meng Nie, Qinhui Ren, Xiang Yu, Hua Li, Hongliang Chen, Mengting He, Zhao Liang, Siyuan Wang, Dongxue Han.  (2023)  Preparation of bimetallic metal–organic frameworks for adsorbing doxycycline hydrochloride from wastewater.  APPLIED ORGANOMETALLIC CHEMISTRY,  37  (9): (e7212).  [PMID:] [10.1002/aoc.7212]
3. Dong Wang, Yumeng Wang, Luheng Jing, Lei Wang, Tonghui Zhang, Xuefen Wang.  (2023)  L-phenylalanine-assisted construction of hierarchically structured Fe(OH)3@Co2(OH)2CO3 with enhanced catalytic activities for the degradation of persistent organic pollutants.  Journal of Cleaner Production,  418  (138220).  [PMID:] [10.1016/j.jclepro.2023.138220]
4. Yating Wang, Chaosheng Peng, Airu Liu, Jinyue Song, Xingang Li, Tao Jiang.  (2023)  Novel intramolecular-tailored g-C3N4 with accelerated charge delivery for photocatalytic tetracycline degradation and hydrogen production: experimental studies and theoretical analyses.  Journal of Materials Chemistry C,  11  (3): (1165-1172).  [PMID:] [10.1039/D2TC04350E]
5. Cheng He, Jiaxin Ma, Huan Xu, Changzi Ge, Ziru Lian.  (2022)  Selective capture and determination of doxycycline in marine sediments by using magnetic imprinting dispersive solid-phase extraction coupled with high performance liquid chromatography.  MARINE POLLUTION BULLETIN,  184  (114215).  [PMID:36307947] [10.1016/j.marpolbul.2022.114215]
6. Dong Wang, Yumeng Wang, Xuefen Wang.  (2022)  Heterostructured ZIF-67@α-MnO2 based nanofibrous membranes for highly effective removal of low-molecular-weight pollutants from wastewater.  SEPARATION AND PURIFICATION TECHNOLOGY,  303  (122225).  [PMID:] [10.1016/j.seppur.2022.122225]
7. Yan-Mei Liang, Hui Yang, Bo Zhou, Yang Chen, Min Yang, Ke-Su Wei, Xiu-Fang Yan, Chao Kang.  (2022)  Waste tobacco leaves derived carbon dots for tetracycline detection: Improving quantitative accuracy with the aid of chemometric model.  ANALYTICA CHIMICA ACTA,  1191  (339269).  [PMID:35033278] [10.1016/j.aca.2021.339269]
8. Yijian Zhao, Qinzhi Wang, Haihua Wang, Hui Zhangsun, Xinyu Sun, Tong Bu, Yingnan Liu, Wenze Wang, Zhihao Xu, Li Wang.  (2021)  Europium-based metal-organic framework containing characteristic metal chains: A novel turn-on fluorescence sensor for simultaneous high-performance detection and removal of tetracycline.  SENSORS AND ACTUATORS B-CHEMICAL,  334  (129610).  [PMID:] [10.1016/j.snb.2021.129610]
9. Yanmin Shen, Wenju Liu, Chen Sun, Paifeng Shi.  (2020)  Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,  65  (5): (2774–2783).  [PMID:] [10.1021/acs.jced.0c00097]
10. Junjian Chen, Xuetao Shi, Ye Zhu, Yunhua Chen, Meng Gao, Huichang Gao, Lei Liu, Lin Wang, Chuanbin Mao, Yingjun Wang.  (2020)  On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer.  Theranostics,  10  (1): ( 109–122).  [PMID:31903109] [10.7150/thno.38388]
11. Yanmin Shen, Wenju Liu, Zehua Bao.  (2019)  Solubility measurement and thermodynamic modeling of Doxycycline Hyclate two binary solvent systems at 276.95–323.75 K.  JOURNAL OF MOLECULAR LIQUIDS,  289  (111138).  [PMID:] [10.1016/j.molliq.2019.111138]

References

1. Guanhua Liu, Luting Wang, Anan Zhao, Leijie Guo, Liya Zhou, Ying He, Li Ma, Yunting Liu, Jing Gao, Yanjun Jiang.  (2023)  Biocatalytic membranes with crosslinked enzyme aggregates for micropollutant removal.  CHEMICAL ENGINEERING JOURNAL,    (147635).  [PMID:23145173] [10.1016/j.cej.2023.147635]
2. Fuhua Wei, Meng Nie, Qinhui Ren, Xiang Yu, Hua Li, Hongliang Chen, Mengting He, Zhao Liang, Siyuan Wang, Dongxue Han.  (2023)  Preparation of bimetallic metal–organic frameworks for adsorbing doxycycline hydrochloride from wastewater.  APPLIED ORGANOMETALLIC CHEMISTRY,  37  (9): (e7212).  [PMID:] [10.1002/aoc.7212]
3. Dong Wang, Yumeng Wang, Luheng Jing, Lei Wang, Tonghui Zhang, Xuefen Wang.  (2023)  L-phenylalanine-assisted construction of hierarchically structured Fe(OH)3@Co2(OH)2CO3 with enhanced catalytic activities for the degradation of persistent organic pollutants.  Journal of Cleaner Production,  418  (138220).  [PMID:] [10.1016/j.jclepro.2023.138220]
4. Yating Wang, Chaosheng Peng, Airu Liu, Jinyue Song, Xingang Li, Tao Jiang.  (2023)  Novel intramolecular-tailored g-C3N4 with accelerated charge delivery for photocatalytic tetracycline degradation and hydrogen production: experimental studies and theoretical analyses.  Journal of Materials Chemistry C,  11  (3): (1165-1172).  [PMID:] [10.1039/D2TC04350E]
5. Cheng He, Jiaxin Ma, Huan Xu, Changzi Ge, Ziru Lian.  (2022)  Selective capture and determination of doxycycline in marine sediments by using magnetic imprinting dispersive solid-phase extraction coupled with high performance liquid chromatography.  MARINE POLLUTION BULLETIN,  184  (114215).  [PMID:36307947] [10.1016/j.marpolbul.2022.114215]
6. Dong Wang, Yumeng Wang, Xuefen Wang.  (2022)  Heterostructured ZIF-67@α-MnO2 based nanofibrous membranes for highly effective removal of low-molecular-weight pollutants from wastewater.  SEPARATION AND PURIFICATION TECHNOLOGY,  303  (122225).  [PMID:] [10.1016/j.seppur.2022.122225]
7. Yan-Mei Liang, Hui Yang, Bo Zhou, Yang Chen, Min Yang, Ke-Su Wei, Xiu-Fang Yan, Chao Kang.  (2022)  Waste tobacco leaves derived carbon dots for tetracycline detection: Improving quantitative accuracy with the aid of chemometric model.  ANALYTICA CHIMICA ACTA,  1191  (339269).  [PMID:35033278] [10.1016/j.aca.2021.339269]
8. Yijian Zhao, Qinzhi Wang, Haihua Wang, Hui Zhangsun, Xinyu Sun, Tong Bu, Yingnan Liu, Wenze Wang, Zhihao Xu, Li Wang.  (2021)  Europium-based metal-organic framework containing characteristic metal chains: A novel turn-on fluorescence sensor for simultaneous high-performance detection and removal of tetracycline.  SENSORS AND ACTUATORS B-CHEMICAL,  334  (129610).  [PMID:] [10.1016/j.snb.2021.129610]
9. Yanmin Shen, Wenju Liu, Chen Sun, Paifeng Shi.  (2020)  Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,  65  (5): (2774–2783).  [PMID:] [10.1021/acs.jced.0c00097]
10. Junjian Chen, Xuetao Shi, Ye Zhu, Yunhua Chen, Meng Gao, Huichang Gao, Lei Liu, Lin Wang, Chuanbin Mao, Yingjun Wang.  (2020)  On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer.  Theranostics,  10  (1): ( 109–122).  [PMID:31903109] [10.7150/thno.38388]
11. Yanmin Shen, Wenju Liu, Zehua Bao.  (2019)  Solubility measurement and thermodynamic modeling of Doxycycline Hyclate two binary solvent systems at 276.95–323.75 K.  JOURNAL OF MOLECULAR LIQUIDS,  289  (111138).  [PMID:] [10.1016/j.molliq.2019.111138]

Solution Calculators