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Doxycycline hyclate - ≥98%, high purity , CAS No.24390-14-5

11 Citations

≥98%

CAS#: 24390-14-5
Formula: C₂₂H₂₄N₂O₈·HCl·0.5H₂O·0.5C₂H₆O
Molecular Weight: 512.94
Beilstein Registry Number: 5702728
MDL number: MFCD07357237
PubChem CID: 54686183

Item Number

D111943

Grouped product items
SKU	Size	Availability	Price
D111943-5g	5g	In stock	$22.90
D111943-25g	25g	In stock	$73.90
D111943-100g	100g	In stock	$236.90

Synthetic tetracycline; matrix metalloprotease inhibitor

View related series

Anti-infection Antibiotic Bacterial Metabolic Enzyme/Protease MMP Parasite Tetracycline antibiotics Tetracyclines

Basic Description

Synonyms	Doxycycline hydrochloride hydrate (JP17) \| Periostat \| AKOS025402170 \| DOXYCYCLINE HYCLATE [VANDF] \| DOXYCYCLINE HYCLATE [ORANGE BOOK] \| Doxycycline hyclate 100 microg/mL in Acetonitrile \| trans-1,3-Pentadiene, analytical standard \| Doxycycline hyclate (i
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Cell permeable: no Primary Target MMP-8 Product does not compete with ATP. Reversible: no Target IC50: 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate.Synthetic tetrac
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Inhibits matrix metalloproteinases at subantimicrobial doses.Doxycycline hyclate is an antibacterial antibiotic, which is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (collagenase-1; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride
INCHI	InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c21-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h24-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);3H,2H2,1H3;21H;1H2/t27-,10+,14+,15-,17-,22-;;;;/m00..../s1
InChi Key	UHHHTIKWXBRCLT-VDBOFHIQSA-N
Canonical SMILES	CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
Isomeric SMILES	CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
WGK Germany	3
RTECS	QI8925000
Alternate CAS	10592-13-9
PubChem CID	54686183
Molecular Weight	512.94
Beilstein	5702728

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
F2424150	Certificate of Analysis	Jun 07, 2024	D111943
F2424151	Certificate of Analysis	Jun 07, 2024	D111943
D2411403	Certificate of Analysis	Mar 25, 2024	D111943
D2411404	Certificate of Analysis	Mar 25, 2024	D111943
C2215483	Certificate of Analysis	Dec 30, 2021	D111943
C2215484	Certificate of Analysis	Dec 30, 2021	D111943
C2215491	Certificate of Analysis	Dec 30, 2021	D111943
F2117115	Certificate of Analysis	Jun 19, 2021	D111943

Chemical and Physical Properties

Solubility	Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
Specific Rotation[α]	-104° (C=1,0.01mol/L HCl(MeOH))

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H400:Very toxic to aquatic life H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	QI8925000
Merck Index	3440

Alternative Products

FAQs and Articles

FAQ

Antibiotics block bacterial protein synthesis

Categories: Technical articles

Tags:

Antibiotics Tetra Aminoglycosides Macrolides Peptidyl transferase inhibitors Antibiotics for cell culture

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Guanhua Liu, Luting Wang, Anan Zhao, Leijie Guo, Liya Zhou, Ying He, Li Ma, Yunting Liu, Jing Gao, Yanjun Jiang. (2023) Biocatalytic membranes with crosslinked enzyme aggregates for micropollutant removal. CHEMICAL ENGINEERING JOURNAL, (147635). [PMID:23145173] [10.1016/j.cej.2023.147635]
2. Fuhua Wei, Meng Nie, Qinhui Ren, Xiang Yu, Hua Li, Hongliang Chen, Mengting He, Zhao Liang, Siyuan Wang, Dongxue Han. (2023) Preparation of bimetallic metal–organic frameworks for adsorbing doxycycline hydrochloride from wastewater. APPLIED ORGANOMETALLIC CHEMISTRY, 37 (9): (e7212). [PMID:] [10.1002/aoc.7212]
3. Dong Wang, Yumeng Wang, Luheng Jing, Lei Wang, Tonghui Zhang, Xuefen Wang. (2023) L-phenylalanine-assisted construction of hierarchically structured Fe(OH)3@Co2(OH)2CO3 with enhanced catalytic activities for the degradation of persistent organic pollutants. Journal of Cleaner Production, 418 (138220). [PMID:] [10.1016/j.jclepro.2023.138220]
4. Yating Wang, Chaosheng Peng, Airu Liu, Jinyue Song, Xingang Li, Tao Jiang. (2023) Novel intramolecular-tailored g-C3N4 with accelerated charge delivery for photocatalytic tetracycline degradation and hydrogen production: experimental studies and theoretical analyses. Journal of Materials Chemistry C, 11 (3): (1165-1172). [PMID:] [10.1039/D2TC04350E]
5. Cheng He, Jiaxin Ma, Huan Xu, Changzi Ge, Ziru Lian. (2022) Selective capture and determination of doxycycline in marine sediments by using magnetic imprinting dispersive solid-phase extraction coupled with high performance liquid chromatography. MARINE POLLUTION BULLETIN, 184 (114215). [PMID:36307947] [10.1016/j.marpolbul.2022.114215]
6. Dong Wang, Yumeng Wang, Xuefen Wang. (2022) Heterostructured ZIF-67@α-MnO2 based nanofibrous membranes for highly effective removal of low-molecular-weight pollutants from wastewater. SEPARATION AND PURIFICATION TECHNOLOGY, 303 (122225). [PMID:] [10.1016/j.seppur.2022.122225]
7. Yan-Mei Liang, Hui Yang, Bo Zhou, Yang Chen, Min Yang, Ke-Su Wei, Xiu-Fang Yan, Chao Kang. (2022) Waste tobacco leaves derived carbon dots for tetracycline detection: Improving quantitative accuracy with the aid of chemometric model. ANALYTICA CHIMICA ACTA, 1191 (339269). [PMID:35033278] [10.1016/j.aca.2021.339269]
8. Yijian Zhao, Qinzhi Wang, Haihua Wang, Hui Zhangsun, Xinyu Sun, Tong Bu, Yingnan Liu, Wenze Wang, Zhihao Xu, Li Wang. (2021) Europium-based metal-organic framework containing characteristic metal chains: A novel turn-on fluorescence sensor for simultaneous high-performance detection and removal of tetracycline. SENSORS AND ACTUATORS B-CHEMICAL, 334 (129610). [PMID:] [10.1016/j.snb.2021.129610]
9. Yanmin Shen, Wenju Liu, Chen Sun, Paifeng Shi. (2020) Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 65 (5): (2774–2783). [PMID:] [10.1021/acs.jced.0c00097]
10. Junjian Chen, Xuetao Shi, Ye Zhu, Yunhua Chen, Meng Gao, Huichang Gao, Lei Liu, Lin Wang, Chuanbin Mao, Yingjun Wang. (2020) On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer. Theranostics, 10 (1): ( 109–122). [PMID:31903109] [10.7150/thno.38388]
11. Yanmin Shen, Wenju Liu, Zehua Bao. (2019) Solubility measurement and thermodynamic modeling of Doxycycline Hyclate two binary solvent systems at 276.95–323.75 K. JOURNAL OF MOLECULAR LIQUIDS, 289 (111138). [PMID:] [10.1016/j.molliq.2019.111138]

References

1. Nijenhuis W et al.. (2020) An optimized toolbox for the optogenetic control of intracellular transport.. J Cell Biol, 219 (4): [PMID:32328628]
2. Pan J et al.. (2020) Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas.. Cancer Res, 80 (13): (2722-2736). [PMID:32332020]
3. Chang CC et al.. (2022) Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation.. Cell Mol Life Sci, 79 (8): (420). [PMID:35833994]
4. Meiring JCM et al.. (2022) Opto-katanin, an optogenetic tool for localized, microtubule disassembly.. Curr Biol, 32 (21): (4660-4674.e6). [PMID:36174574]
5. Viau A et al.. (2020) Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.. J Am Soc Nephrol, 31 (5): (1035-1049). [PMID:32238474]
6. Isobe SY et al.. (2021) Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.. Cell Rep, 36 (2): (109383). [PMID:34260925]
7. Yannick Bongrand,Marie-Claude Blais,Kate Alexander. (2013-04-02) Atypical pneumonia associated with a Mycoplasma isolate in a kitten.. The Canadian veterinary journal = La revue veterinaire canadienne, 53 ((10)): (1109-1113). [PMID:23543932]
8. J Delaloye,G Greub. (2013-05-24) [Q fever, a zoonosis often overlooked].. Revue medicale suisse, 9 ((383)): (879-884). [PMID:23697082]
9. Christine M Khosropour,Lisa E Manhart,Danny V Colombara,Catherine W Gillespie,M Sylvan Lowens,Patricia A Totten,Matthew R Golden,Jane Simoni. (2013-10-10) Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: a prospective cohort study.. Sexually transmitted infections, 90 ((1)): (3-7). [PMID:24106340]
10. Komuraiah Myakala,Sarah Motta,Heini Murer,Carsten A Wagner,Robert Koesters,Jürg Biber,Nati Hernando. (2014-02-21) Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice.. American journal of physiology. Renal physiology, 306 ((8)): (F833-F843). [PMID:24553430]
11. Emerentiana Veronica Oud,Nynke Hesselina Neeltje de Vrieze,Arjan de Meij,Henry John C de Vries. (2014-05-03) Pitfalls in the diagnosis and management of inguinal lymphogranuloma venereum: important lessons from a case series.. Sexually transmitted infections, 90 ((4)): (279-282). [PMID:24787368]
12. M P Do,C Neut,E Delcourt,T Seixas Certo,J Siepmann,F Siepmann. (2014-05-17) In situ forming implants for periodontitis treatment with improved adhesive properties.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88 ((2)): (342-350). [PMID:24833006]
13. Charlotte Starke,Hannah Betz,Linda Hickmann,Peter Lachmann,Björn Neubauer,Jeffrey B Kopp,Maria Luisa S Sequeira-Lopez,R Ariel Gomez,Bernd Hohenstein,Vladimir T Todorov,Christian P M Hugo. (2014-06-07) Renin lineage cells repopulate the glomerular mesangium after injury.. Journal of the American Society of Nephrology : JASN, 26 ((1)): (48-54). [PMID:24904091]
14. Shumei Song,Jaffer A Ajani,Soichiro Honjo,Dipen M Maru,Qiongrong Chen,Ailing W Scott,Todd R Heallen,Lianchun Xiao,Wayne L Hofstetter,Brian Weston,Jeffrey H Lee,Roopma Wadhwa,Kazuki Sudo,John R Stroehlein,James F Martin,Mien-Chie Hung,Randy L Johnson. (2014-06-08) Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties.. Cancer research, 74 ((15)): (4170-4182). [PMID:24906622]
15. Jia Wang,Eagle S H Chu,Hai-Yong Chen,Kwan Man,Minnie Y Y Go,Xiao Ru Huang,Hui Yao Lan,Joseph J Y Sung,Jun Yu. (2014-10-31) microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway.. Oncotarget, 6 ((9)): (7325-7338). [PMID:25356754]
16. Rebekah K Franklin,Sarah A Marcus,Adel M Talaat,Butch K KuKanich,Ruth Sullivan,Lisa A Krugner-Higby,Timothy D Heath. (2015-06-03) A Novel Loading Method for Doxycycline Liposomes for Intracellular Drug Delivery: Characterization of In Vitro and In Vivo Release Kinetics and Efficacy in a J774A.1 Cell Line Model of Mycobacterium smegmatis Infection.. Drug metabolism and disposition: the biological fate of chemicals, 43 ((8)): (1236-1245). [PMID:26033620]
17. Jolien S de Groot,Max Ak Ratze,Miranda van Amersfoort,Tanja Eisemann,Eva J Vlug,Mijanou T Niklaas,Suet-Feung Chin,Carlos Caldas,Paul J van Diest,Jos Jonkers,Johan de Rooij,Patrick Wb Derksen. (2018-05-19) αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.. The Journal of pathology, 245 ((4)): (456-467). [PMID:29774524]
18. Aruljothi Mariappan,Komal Soni,Kenji Schorpp,Fan Zhao,Amin Minakar,Xiangdong Zheng,Sunit Mandad,Iris Macheleidt,Anand Ramani,Tomáš Kubelka,Maciej Dawidowski,Kristina Golfmann,Arpit Wason,Chunhua Yang,Judith Simons,Hans-Günther Schmalz,Anthony A Hyman,Ritu Aneja,Roland Ullrich,Henning Urlaub,Margarete Odenthal,Reinhardt Büttner,Haitao Li,Michael Sattler,Kamyar Hadian,Jay Gopalakrishnan. (2018-12-12) Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.. The EMBO journal, 38 ((2)): [PMID:30530478]
19. Ji Hae Lee,Jee Young Sung,Eun Kyung Choi,Hyun-Kyoung Yoon,Bo Ram Kang,Eun Kyung Hong,Byung-Kiu Park,Yong-Nyun Kim,Seung Bae Rho,Kyungsil Yoon. (2019-02-14) C/EBPβ Is a Transcriptional Regulator of Wee1 at the G₂/M Phase of the Cell Cycle.. Cells, 8 ((2)): [PMID:30754676]
20. Sofía Mira-Martínez,Anastasia K Pickford,Núria Rovira-Graells,Pieter Guetens,Elisabet Tintó-Font,Alfred Cortés,Anna Rosanas-Urgell. (2019-02-21) Identification of Antimalarial Compounds That Require CLAG3 for Their Uptake by Plasmodium falciparum-Infected Erythrocytes.. Antimicrobial agents and chemotherapy, 63 ((5)): [PMID:30782998]
21. Clay O Lacefield,Eftychios A Pnevmatikakis,Liam Paninski,Randy M Bruno. (2019-02-21) Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex.. Cell reports, 26 ((8)): (2000-2008). [PMID:30784583]
22. Eric M Jones,Rishi Jajoo,Daniel Cancilla,Nathan B Lubock,Jeffrey Wang,Megan Satyadi,Rocky Cheung,Claire de March,Joshua S Bloom,Hiroaki Matsunami,Sriram Kosuri. (2019-03-25) A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing.. Cell systems, 8 ((3)): (254-260). [PMID:30904378]
23. Ryan M J Genga,Eric M Kernfeld,Krishna M Parsi,Teagan J Parsons,Michael J Ziller,René Maehr. (2019-04-18) Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.. Cell reports, 27 ((3)): (708-718). [PMID:30995470]
24. Ileana Bortolomai,Monica Sandri,Elena Draghici,Elena Fontana,Elisabetta Campodoni,Genni Enza Marcovecchio,Francesca Ferrua,Laura Perani,Antonello Spinelli,Tamara Canu,Marco Catucci,Tiziano Di Tomaso,Lucia Sergi Sergi,Antonio Esposito,Angelo Lombardo,Luigi Naldini,Anna Tampieri,Georg A Hollander,Anna Villa,Marita Bosticardo. (2019-05-30) Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches.. Stem cells translational medicine, 8 ((10)): (1107-1122). [PMID:31140762]
25. Maximilian Heumüller,Caspar Glock,Vidhya Rangaraju,Anne Biever,Erin M Schuman. (2019-07-17) A genetically encodable cell-type-specific protein synthesis inhibitor.. Nature methods, 16 ((8)): (699-702). [PMID:31308551]
26. Leire Arreal,Marco Piva,Sonia Fernández,Ajinkya Revandkar,Ariane Schaub-Clerigué,Josep Villanueva,Amaia Zabala-Letona,Mikel Pujana,Ianire Astobiza,Ana Rosa Cortazar,Ivana Hermanova,Laura Bozal-Basterra,Amaia Arruabarrena-Aristorena,Jana R Crespo,Lorea Valcarcel-Jimenez,Patricia Zúñiga-García,Francesc Canals,Veronica Torrano,Rosa Barrio,James D Sutherland,Andrea Alimonti,Natalia Martin-Martin,Arkaitz Carracedo. (2019-10-02) Targeting PML in triple negative breast cancer elicits growth suppression and senescence.. Cell death and differentiation, 27 ((4)): (1186-1199). [PMID:31570853]
27. Clarissa Valdez,Daniel Ysselstein,Tiffany J Young,Jianbin Zheng,Dimitri Krainc. (2019-10-11) Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity.. Human molecular genetics, 29 ((5)): (716-726). [PMID:31600775]
28. Silvia Ferrè,Yingfeng Deng,Sarah C Huen,Christopher Y Lu,Philipp E Scherer,Peter Igarashi,Orson W Moe. (2019-10-12) Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.. Kidney international, 96 ((6)): (1359-1373). [PMID:31601454]
29. Nichole Eshleman,Xiangxia Luo,Andrew Capaldi,J Ross Buchan. (2019-10-12) Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast.. RNA (New York, N.Y.), 26 ((1)): (10-18). [PMID:31601735]
30. Tomohide Kurahashi,Yuichi Yoshida,Satoshi Ogura,Mayumi Egawa,Kunimaro Furuta,Hayato Hikita,Takahiro Kodama,Ryotaro Sakamori,Shinichi Kiso,Yoshihiro Kamada,I-Ching Wang,Hidetoshi Eguchi,Eiichi Morii,Yuichiro Doki,Masaki Mori,Vladimir V Kalinichenko,Tomohide Tatsumi,Tetsuo Takehara. (2019-11-02) Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice.. Cellular and molecular gastroenterology and hepatology, 9 ((3)): (425-446). [PMID:31669262]
31. Maria Eugenia Sabatino,Andrés Castellaro,Ana C Racca,Sofía Carbajosa González,Maria Florencia Pansa,Gastón Soria,Jose Luis Bocco. (2019-12-12) Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence.. Frontiers in cell and developmental biology, 7 (297-297). [PMID:31824948]
32. Alec M DeSimone,John Leszyk,Kathryn Wagner,Charles P Emerson. (2019-12-18) Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy.. Science advances, 5 ((12)): (eaaw7099-eaaw7099). [PMID:31844661]
33. Belinda Yau,Zachary Blood,Yousun An,Zhiduan Su,Melkam A Kebede. (2019-12-21) Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells.. Scientific reports, 9 ((1)): (19466-19466). [PMID:31857633]
34. Dane Z Hazelbaker,Amanda Beccard,Gabriella Angelini,Patrizia Mazzucato,Angelica Messana,Daisy Lam,Kevin Eggan,Lindy E Barrett. (2020-01-22) A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells.. Scientific reports, 10 ((1)): (635-635). [PMID:31959800]
35. Tomohiro Minakawa,Yasuharu Kanki,Kae Nakamura,Jun K Yamashita. (2020-01-26) Protein kinase A accelerates the rate of early stage differentiation of pluripotent stem cells.. Biochemical and biophysical research communications, 524 ((1)): (57-63). [PMID:31980180]
36. Xin Li,Yueshui Zhao,Chuan Chen,Li Yang,Hyun-Ho Lee,Zening Wang,Ningyan Zhang,Mikhail G Kolonin,Zhiqiang An,Xin Ge,Philipp E Scherer,Kai Sun. (2020-01-29) Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity.. Molecular and cellular biology, 40 ((8)): [PMID:31988105]
37. Joaquin Urdinez,Aleksandar Boro,Alekhya Mazumdar,Matthias Je Arlt,Roman Muff,Sander M Botter,Beata Bode-Lesniewska,Bruno Fuchs,Jess G Snedeker,Ana Gvozdenovic. (2020-02-07) The miR-143/145 Cluster, a Novel Diagnostic Biomarker in Chondrosarcoma, Acts as a Tumor Suppressor and Directly Inhibits Fascin-1.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35 ((6)): (1077-1091). [PMID:32027760]
38. Juan A Ortega,Elizabeth L Daley,Sukhleen Kour,Marisa Samani,Liana Tellez,Haley S Smith,Elizabeth A Hall,Y Taylan Esengul,Yung-Hsu Tsai,Tania F Gendron,Christopher J Donnelly,Teepu Siddique,Jeffrey N Savas,Udai B Pandey,Evangelos Kiskinis. (2020-02-16) Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.. Neuron, 106 ((1)): (90-107). [PMID:32059759]
39. Yosuke Watanabe,Kazuhiro Watanabe,Daisuke Fujioka,Kazuto Nakamura,Takamitsu Nakamura,Manabu Uematsu,Markus M Bachschmid,Reiko Matsui,Kiyotaka Kugiyama. (2020-03-07) Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34 ((4)): (5827-5837). [PMID:32141127]
40. Alexandra Gunne-Braden,Adrienne Sullivan,Borzo Gharibi,Rahuman S M Sheriff,Alok Maity,Yi-Fang Wang,Amelia Edwards,Ming Jiang,Michael Howell,Robert Goldstone,Roy Wollman,Philip East,Silvia D M Santos. (2020-04-18) GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells.. Cell stem cell, 26 ((5)): (693-706). [PMID:32302522]
41. Robin Schwarzer,Huipeng Jiao,Laurens Wachsmuth,Achim Tresch,Manolis Pasparakis. (2020-05-05) FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.. Immunity, 52 ((6)): (978-993). [PMID:32362323]
42. Linna Zhou,Anne C Wolfes,Yichen Li,Danny C W Chan,Ho Ko,Francis G Szele,Hagan Bayley. (2020-06-17) Lipid-Bilayer-Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions.. Advanced materials (Deerfield Beach, Fla.), 32 ((31)): (e2002183-e2002183). [PMID:32537827]
43. Syed Usman Enam,Boris Zinshteyn,Daniel H Goldman,Madeline Cassani,Nathan M Livingston,Geraldine Seydoux,Rachel Green. (2020-08-28) Puromycin reactivity does not accurately localize translation at the subcellular level.. eLife, 9 [PMID:32844748]
44. Yu Chen Feng,Xiao Ying Liu,Liu Teng,Qiang Ji,Yongyan Wu,Jin Ming Li,Wei Gao,Yuan Yuan Zhang,Ting La,Hessam Tabatabaee,Xu Guang Yan,M Fairuz B Jamaluddin,Didi Zhang,Su Tang Guo,Rodney J Scott,Tao Liu,Rick F Thorne,Xu Dong Zhang,Lei Jin. (2020-10-07) c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis.. Nature communications, 11 ((1)): (4980-4980). [PMID:33020477]
45. Aindriu R R Maguire,Robert W E Crozier,Katie D Hunter,Steven M Claypool,Val A Fajardo,Paul J LeBlanc,Adam J MacNeil. (2021-04-26) Tafazzin Modulates Allergen-Induced Mast Cell Inflammatory Mediator Secretion.. ImmunoHorizons, 5 ((4)): (182-192). [PMID:33895725]
46. Elizabeth M Hill,Christopher D Howard,Tracy L Bale,Eldin Jašarević. (2021-05-13) Perinatal exposure to tetracycline contributes to lasting developmental effects on offspring.. Animal microbiome, 3 ((1)): (37-37). [PMID:33975649]
47. Daniel Gradeci,Anna Bove,Giulia Vallardi,Alan R Lowe,Shiladitya Banerjee,Guillaume Charras. (2021-05-21) Cell-scale biophysical determinants of cell competition in epithelia.. eLife, 10 [PMID:34014166]
48. Shuhei Aihara,Satoshi Fujimoto,Richi Sakaguchi,Takeshi Imai. (2021-06-24) BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling.. Cell reports, 35 ((12)): (109276-109276). [PMID:34161760]
49. Jaclyn M Einstein,Mark Perelis,Isaac A Chaim,Jitendra K Meena,Julia K Nussbacher,Alexandra T Tankka,Brian A Yee,Heyuan Li,Assael A Madrigal,Nicholas J Neill,Archana Shankar,Siddhartha Tyagi,Thomas F Westbrook,Gene W Yeo. (2021-07-04) Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.. Molecular cell, 81 ((15)): (3048-3064). [PMID:34216543]
50. Bo-Ruei Chen,Yinan Wang,Anthony Tubbs,Dali Zong,Faith C Fowler,Nicholas Zolnerowich,Wei Wu,Amelia Bennett,Chun-Chin Chen,Wendy Feng,Andre Nussenzweig,Jessica K Tyler,Barry P Sleckman. (2021-09-04) LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.. eLife, 10 [PMID:34477552]
51. Xingjie Ren,Mengchi Wang,Bingkun Li,Kirsty Jamieson,Lina Zheng,Ian R Jones,Bin Li,Maya Asami Takagi,Jerry Lee,Lenka Maliskova,Tsz Wai Tam,Miao Yu,Rong Hu,Lindsay Lee,Armen Abnousi,Gang Li,Yun Li,Ming Hu,Bing Ren,Wei Wang,Yin Shen. (2021-09-16) Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath.. Science advances, 7 ((38)): (eabi4360-eabi4360). [PMID:34524848]
52. Yueru Li,Basma Baccouche,Olamide Olayinka,Anara Serikbaeva,Andrius Kazlauskas. (2021-09-21) The Role of the Wnt Pathway in VEGF/Anti-VEGF-Dependent Control of the Endothelial Cell Barrier.. Investigative ophthalmology & visual science, 62 ((12)): (17-17). [PMID:34542556]
53. Topaz Altman,Ariel Ionescu,Amjad Ibraheem,Dominik Priesmann,Tal Gradus-Pery,Luba Farberov,Gayster Alexandra,Natalia Shelestovich,Ruxandra Dafinca,Noam Shomron,Florence Rage,Kevin Talbot,Michael E Ward,Amir Dori,Marcus Krüger,Eran Perlson. (2021-11-27) Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins.. Nature communications, 12 ((1)): (6914-6914). [PMID:34824257]
54. Zhen Zhang,Wen-Zhao Yang,Zhen-Zhen Zhu,Qian-Qian Hu,Yan-Feng Chen,Hui He,Yong-Xiong Chen,Zu-Guo Liu. (2014-04-12) Therapeutic effects of topical doxycycline in a benzalkonium chloride-induced mouse dry eye model.. Investigative ophthalmology & visual science, 55 ((5)): (2963-2974). [PMID:24722696]
55. Maike Stahlhut,Adrian Schwarzer,Matthias Eder,Min Yang,Zhixiong Li,Michael Morgan,Axel Schambach,Olga S Kustikova. (2015-06-27) Lentiviral vector system for coordinated constitutive and drug controlled tetracycline-regulated gene co-expression.. Biomaterials, 63 (189-201). [PMID:26113075]
56. Jose Luis Sardina,Samuel Collombet,Tian V Tian,Antonio Gómez,Bruno Di Stefano,Clara Berenguer,Justin Brumbaugh,Ralph Stadhouders,Carolina Segura-Morales,Marta Gut,Ivo G Gut,Simon Heath,Sergi Aranda,Luciano Di Croce,Konrad Hochedlinger,Denis Thieffry,Thomas Graf. (2018-09-18) Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.. Cell stem cell, 23 ((5)): (727-741). [PMID:30220521]
57. Jennifer C Jones,Constance D Brindley,Nicholas H Elder,Martin G Myers,Michael W Rajala,Christopher M Dekaney,Eoin N McNamee,Mark R Frey,Noah F Shroyer,Peter J Dempsey. (2019-03-05) Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.. Cellular and molecular gastroenterology and hepatology, 7 ((3)): (533-554). [PMID:30827941]
58. Celien Lismont,Janet Koster,Sarah Provost,Myriam Baes,Paul P Van Veldhoven,Hans R Waterham,Marc Fransen. (2019-05-28) Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting.. Biochimica et biophysica acta. Biomembranes, 1861 ((10)): (182991-182991). [PMID:31129117]
59. Agnese Cristini,Giulia Ricci,Sébastien Britton,Simona Salimbeni,Shar-Yin Naomi Huang,Jessica Marinello,Patrick Calsou,Yves Pommier,Gilles Favre,Giovanni Capranico,Natalia Gromak,Olivier Sordet. (2019-09-19) Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.. Cell reports, 28 ((12)): (3167-3181). [PMID:31533039]
60. Jelena Tosic,Gwang-Jin Kim,Mihael Pavlovic,Chiara M Schröder,Sophie-Luise Mersiowsky,Margareta Barg,Alexis Hofherr,Simone Probst,Michael Köttgen,Lutz Hein,Sebastian J Arnold. (2019-12-04) Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state.. Nature cell biology, 21 ((12)): (1518-1531). [PMID:31792383]
61. Ze-Yi Zheng,Meenakshi Anurag,Jonathan T Lei,Jin Cao,Purba Singh,Jianheng Peng,Hilda Kennedy,Nhu-Chau Nguyen,Yue Chen,Philip Lavere,Jing Li,Xin-Hui Du,Burcu Cakar,Wei Song,Beom-Jun Kim,Jiejun Shi,Sinem Seker,Doug W Chan,Guo-Qiang Zhao,Xi Chen,Kimberly C Banks,Richard B Lanman,Maryam Nemati Shafaee,Xiang H-F Zhang,Suhas Vasaikar,Bing Zhang,Susan G Hilsenbeck,Wei Li,Charles E Foulds,Matthew J Ellis,Eric C Chang. (2020-03-07) Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer.. Cancer cell, 37 ((3)): (387-402). [PMID:32142667]
62. Pascal Stücheli,Simon Sieber,David W Fuchs,Leo Scheller,Tobias Strittmatter,Pratik Saxena,Karl Gademann,Martin Fussenegger. (2020-05-19) Genetically encoded betaxanthin-based small-molecular fluorescent reporter for mammalian cells.. Nucleic acids research, 48 ((12)): (e67-e67). [PMID:32421771]
63. Joseph A Giovinazzo,Russell P Thomson,Nailya Khalizova,Patrick J Zager,Nirav Malani,Enrique Rodriguez-Boulan,Jayne Raper,Ryan Schreiner. (2020-05-20) Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity.. eLife, 9 [PMID:32427098]
64. Burcu Vitrinel,Dylan E Iannitelli,Esteban O Mazzoni,Lionel Christiaen,Christine Vogel. (2020-07-09) Simple Method to Quantify Protein Abundances from 1000 Cells.. ACS omega, 5 ((25)): (15537-15546). [PMID:32637829]
65. Kenta Tsuchiya,Hisato Hayashi,Momoko Nishina,Masako Okumura,Yoshikatsu Sato,Masato T Kanemaki,Gohta Goshima,Tomomi Kiyomitsu. (2020-11-14) Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.. Current biology : CB, 31 ((1)): (115-127). [PMID:33186548]
66. Keishi Otsu,Hiroko Ida-Yonemochi,Shojiro Ikezaki,Masatsugu Ema,Jiro Hitomi,Hayato Ohshima,Hidemitsu Harada. (2021-01-22) Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.. Development (Cambridge, England), 148 ((4)): [PMID:33472844]
67. Wencan He,Lamia Azzi-Martin,Valérie Velasco,Philippe Lehours,Pierre Dubus,Mojgan Djavaheri-Mergny,Armelle Ménard. (2021-03-05) The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1.. PLoS pathogens, 17 ((3)): (e1009320-e1009320). [PMID:33662035]
68. Yilin Fan,Tobias Meyer. (2021-07-29) Molecular control of cell density-mediated exit to quiescence.. Cell reports, 36 ((4)): (109436-109436). [PMID:34320337]
69. Chunlei Shao,Pengbo Lou,Ruiqi Liu,Xueyun Bi,Guilin Li,Xu Yang,Xiaole Sheng,Jiuzhi Xu,Cong Lv,Zhengquan Yu. (2021-08-03) Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.. Frontiers in cell and developmental biology, 9 (691050-691050). [PMID:34336839]
70. Gen Li,Tianquan Yang,Yanling Chen,Jianping Bao,Di Wu,Xiaohan Hu,Chenxi Feng,Lixiao Xu,Mei Li,Gang Li,Meifang Jin,Yunyun Xu,Rui Zhang,Guanghui Qian,Jian Pan. (2021-09-07) USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1.. Frontiers in pharmacology, 12 (720307-720307). [PMID:34483932]
71. Alexander K Kunisky,Vivian I Anyaeche,R Samuel Herron,Christopher Y Park,Hun-Way Hwang. (2021-10-14) Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis.. Cell reports, 37 ((2)): (109815-109815). [PMID:34644577]
72. Guanhua Liu, Luting Wang, Anan Zhao, Leijie Guo, Liya Zhou, Ying He, Li Ma, Yunting Liu, Jing Gao, Yanjun Jiang. (2023) Biocatalytic membranes with crosslinked enzyme aggregates for micropollutant removal. CHEMICAL ENGINEERING JOURNAL, (147635). [PMID:23145173] [10.1016/j.cej.2023.147635]
73. Fuhua Wei, Meng Nie, Qinhui Ren, Xiang Yu, Hua Li, Hongliang Chen, Mengting He, Zhao Liang, Siyuan Wang, Dongxue Han. (2023) Preparation of bimetallic metal–organic frameworks for adsorbing doxycycline hydrochloride from wastewater. APPLIED ORGANOMETALLIC CHEMISTRY, 37 (9): (e7212). [PMID:] [10.1002/aoc.7212]
74. Dong Wang, Yumeng Wang, Luheng Jing, Lei Wang, Tonghui Zhang, Xuefen Wang. (2023) L-phenylalanine-assisted construction of hierarchically structured Fe(OH)3@Co2(OH)2CO3 with enhanced catalytic activities for the degradation of persistent organic pollutants. Journal of Cleaner Production, 418 (138220). [PMID:] [10.1016/j.jclepro.2023.138220]
75. Yating Wang, Chaosheng Peng, Airu Liu, Jinyue Song, Xingang Li, Tao Jiang. (2023) Novel intramolecular-tailored g-C3N4 with accelerated charge delivery for photocatalytic tetracycline degradation and hydrogen production: experimental studies and theoretical analyses. Journal of Materials Chemistry C, 11 (3): (1165-1172). [PMID:] [10.1039/D2TC04350E]
76. Cheng He, Jiaxin Ma, Huan Xu, Changzi Ge, Ziru Lian. (2022) Selective capture and determination of doxycycline in marine sediments by using magnetic imprinting dispersive solid-phase extraction coupled with high performance liquid chromatography. MARINE POLLUTION BULLETIN, 184 (114215). [PMID:36307947] [10.1016/j.marpolbul.2022.114215]
77. Dong Wang, Yumeng Wang, Xuefen Wang. (2022) Heterostructured ZIF-67@α-MnO2 based nanofibrous membranes for highly effective removal of low-molecular-weight pollutants from wastewater. SEPARATION AND PURIFICATION TECHNOLOGY, 303 (122225). [PMID:] [10.1016/j.seppur.2022.122225]
78. Yan-Mei Liang, Hui Yang, Bo Zhou, Yang Chen, Min Yang, Ke-Su Wei, Xiu-Fang Yan, Chao Kang. (2022) Waste tobacco leaves derived carbon dots for tetracycline detection: Improving quantitative accuracy with the aid of chemometric model. ANALYTICA CHIMICA ACTA, 1191 (339269). [PMID:35033278] [10.1016/j.aca.2021.339269]
79. Yijian Zhao, Qinzhi Wang, Haihua Wang, Hui Zhangsun, Xinyu Sun, Tong Bu, Yingnan Liu, Wenze Wang, Zhihao Xu, Li Wang. (2021) Europium-based metal-organic framework containing characteristic metal chains: A novel turn-on fluorescence sensor for simultaneous high-performance detection and removal of tetracycline. SENSORS AND ACTUATORS B-CHEMICAL, 334 (129610). [PMID:] [10.1016/j.snb.2021.129610]
80. Yanmin Shen, Wenju Liu, Chen Sun, Paifeng Shi. (2020) Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 65 (5): (2774–2783). [PMID:] [10.1021/acs.jced.0c00097]
81. Junjian Chen, Xuetao Shi, Ye Zhu, Yunhua Chen, Meng Gao, Huichang Gao, Lei Liu, Lin Wang, Chuanbin Mao, Yingjun Wang. (2020) On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer. Theranostics, 10 (1): ( 109–122). [PMID:31903109] [10.7150/thno.38388]
82. Yanmin Shen, Wenju Liu, Zehua Bao. (2019) Solubility measurement and thermodynamic modeling of Doxycycline Hyclate two binary solvent systems at 276.95–323.75 K. JOURNAL OF MOLECULAR LIQUIDS, 289 (111138). [PMID:] [10.1016/j.molliq.2019.111138]

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