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Doxycycline hyclate - ≥98%, high purity , CAS No.24390-14-5

7 Citations

≥98%

CAS#: 24390-14-5
Formula: C₂₂H₂₄N₂O₈·HCl·0.5H₂O·0.5C₂H₆O
Molecular Weight: 512.94
Beilstein Registry Number: 5702728
MDL number: MFCD07357237
PubChem CID: 54686183

Item Number

D111943

Grouped product items
SKU	Size	Availability	Price
D111943-5g	5g	In stock	$22.90
D111943-25g	25g	In stock	$73.90
D111943-100g	100g	In stock	$236.90

Synthetic tetracycline; matrix metalloprotease inhibitor

View related series

Tetracycline antibiotics Tetracyclines

Basic Description

Synonyms	Doxycycline hydrochloride hydrate (JP17) \| Periostat \| AKOS025402170 \| DOXYCYCLINE HYCLATE [VANDF] \| DOXYCYCLINE HYCLATE [ORANGE BOOK] \| Doxycycline hyclate 100 microg/mL in Acetonitrile \| trans-1,3-Pentadiene, analytical standard \| Doxycycline hyclate (i
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Cell permeable: no Primary Target MMP-8 Product does not compete with ATP. Reversible: no Target IC50: 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate.Synthetic tetrac
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Inhibits matrix metalloproteinases at subantimicrobial doses.Doxycycline hyclate is an antibacterial antibiotic, which is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (collagenase-1; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

Associated Targets(non-human)

SARS-CoV-2 (38078 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride
INCHI	InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c21-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h24-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);3H,2H2,1H3;21H;1H2/t27-,10+,14+,15-,17-,22-;;;;/m00..../s1
InChi Key	UHHHTIKWXBRCLT-VDBOFHIQSA-N
Canonical SMILES	CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
Isomeric SMILES	CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
WGK Germany	3
RTECS	QI8925000
Alternate CAS	10592-13-9
PubChem CID	54686183
Molecular Weight	512.94
Beilstein	5702728

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
F2424150	Certificate of Analysis	Jun 07, 2024	D111943
F2424151	Certificate of Analysis	Jun 07, 2024	D111943
D2411403	Certificate of Analysis	Mar 25, 2024	D111943
D2411404	Certificate of Analysis	Mar 25, 2024	D111943
C2215483	Certificate of Analysis	Dec 30, 2021	D111943
C2215484	Certificate of Analysis	Dec 30, 2021	D111943
C2215491	Certificate of Analysis	Dec 30, 2021	D111943
F2117115	Certificate of Analysis	Jun 19, 2021	D111943

Chemical and Physical Properties

Solubility	Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
Specific Rotation[α]	-104° (C=1,0.01mol/L HCl(MeOH))

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H400:Very toxic to aquatic life H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	QI8925000
Merck Index	3440

Alternative Products

FAQs and Articles

FAQ

Antibiotics block bacterial protein synthesis

Categories: Technical articles

Tags:

Antibiotics Tetra Aminoglycosides Macrolides Peptidyl transferase inhibitors Antibiotics for cell culture

Citations of This Product

1. Guanhua Liu, Luting Wang, Anan Zhao, Leijie Guo, Liya Zhou, Ying He, Li Ma, Yunting Liu, Jing Gao, Yanjun Jiang. (2023) Biocatalytic membranes with crosslinked enzyme aggregates for micropollutant removal. CHEMICAL ENGINEERING JOURNAL, (147635). [PMID:23145173]
2. Fuhua Wei, Meng Nie, Qinhui Ren, Xiang Yu, Hua Li, Hongliang Chen, Mengting He, Zhao Liang, Siyuan Wang, Dongxue Han. (2023) Preparation of bimetallic metal–organic frameworks for adsorbing doxycycline hydrochloride from wastewater. APPLIED ORGANOMETALLIC CHEMISTRY, 37 (9): (e7212). [PMID:]
3. Dong Wang, Yumeng Wang, Luheng Jing, Lei Wang, Tonghui Zhang, Xuefen Wang. (2023) L-phenylalanine-assisted construction of hierarchically structured Fe(OH)3@Co2(OH)2CO3 with enhanced catalytic activities for the degradation of persistent organic pollutants. Journal of Cleaner Production, 418 (138220). [PMID:]
4. Yating Wang, Chaosheng Peng, Airu Liu, Jinyue Song, Xingang Li, Tao Jiang. (2023) Novel intramolecular-tailored g-C3N4 with accelerated charge delivery for photocatalytic tetracycline degradation and hydrogen production: experimental studies and theoretical analyses. Journal of Materials Chemistry C, 11 (3): (1165-1172). [PMID:]
5. Cheng He, Jiaxin Ma, Huan Xu, Changzi Ge, Ziru Lian. (2022) Selective capture and determination of doxycycline in marine sediments by using magnetic imprinting dispersive solid-phase extraction coupled with high performance liquid chromatography. MARINE POLLUTION BULLETIN, 184 (114215). [PMID:36307947]
6. Dong Wang, Yumeng Wang, Xuefen Wang. (2022) Heterostructured ZIF-67@α-MnO2 based nanofibrous membranes for highly effective removal of low-molecular-weight pollutants from wastewater. SEPARATION AND PURIFICATION TECHNOLOGY, 303 (122225). [PMID:]
7. Yan-Mei Liang, Hui Yang, Bo Zhou, Yang Chen, Min Yang, Ke-Su Wei, Xiu-Fang Yan, Chao Kang. (2022) Waste tobacco leaves derived carbon dots for tetracycline detection: Improving quantitative accuracy with the aid of chemometric model. ANALYTICA CHIMICA ACTA, 1191 (339269). [PMID:35033278]

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