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Droxinostat - ≥96%, high purity , CAS No.99873-43-5, Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 8

  • Moligand™
  • ≥96%
Item Number
D127578
Grouped product items
SKUSizeAvailabilityPrice Qty
D127578-1mg
1mg
In stock
$28.90
D127578-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$63.90
D127578-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$105.90
D127578-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$238.90
D127578-50mg
50mg
In stock
$450.90
D127578-100mg
100mg
In stock
$725.90
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Selective HDAC3, HDAC6 and HDAC8 inhibitor

View related series
histone deacetylase 3 Inhibitor histone deacetylase 6 Inhibitor histone deacetylase 8 Inhibitor

Basic Description

SynonymsDroxinostat|99873-43-5|4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide|NS 41080|MLS000109046|SMR000104993|XCH|NS41080|NS-41080|CBMicro_030914|CBChromo1_000102|MLS006011918|cid_568416|GTPL8464|SCHEMBL2345192|CHEMBL1526649|BDBM53719|CHEBI:94504|Droxinostat
Specifications & PurityMoligand™, ≥96%
Biochemical and Physiological MechanismsDroxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 (IC50 at 16.9 ,2.47 and 1.46 μM, respectively).Selective HDAC3, HDAC6 and HDAC8 inhibitor (IC 50 values are 16.9, 2.47 and 1.46 μM for HDAC3, 6 and 8 respectively). Induces apoptosis. Show
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 8
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Droxinostat

Associated Targets

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SNCA Tchem Alpha-synuclein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSPA5 Tchem Endoplasmic reticulum chaperone BiP 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide
INCHI InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
InChi Key JHSXDAWGLCZYSM-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
Isomeric SMILES CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
WGK Germany 3
PubChem CID 568416
Molecular Weight 243.69

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot NumberCertificate TypeDateItem
J2114292Certificate of AnalysisJul 10, 2023 D127578
J2114343Certificate of AnalysisJul 10, 2023 D127578
J2114344Certificate of AnalysisJul 10, 2023 D127578
J2114345Certificate of AnalysisJul 10, 2023 D127578
J2114346Certificate of AnalysisJul 10, 2023 D127578
J2114418Certificate of AnalysisJul 10, 2023 D127578

Chemical and Physical Properties

SolubilityDMSO 49 mg/mL Water <1 mg/mL Ethanol 49 mg/mL

Safety and Hazards(GHS)

Pictogram(s) GHS05,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H318:Causes serious eye damage

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P317:Get emergency medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

References

1. Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y et al..  (2010)  Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands..  Mol Cancer Ther,  9  (1): (246-56).  [PMID:20053768]

Solution Calculators

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