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DS-1971a - 98%, high purity , CAS No.1450595-86-4, Inhibitor of Na v1.7

Moligand™
≥98%

CAS#: 1450595-86-4
Formula: C₂₀H₂₁ClFN₅O₃S
Molecular Weight: 465.93
PubChem CID: 71711862

Item Number

D412696

Grouped product items
SKU	Size	Availability	Price
D412696-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$127.90
D412696-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$273.90
D412696-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$431.90
D412696-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$715.90
D412696-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90
D412696-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,358.90

View related series

Nav1.7 Inhibitor

Basic Description

Synonyms	DS-1971a\|1450595-86-4\|EHV5F71MBF\|DS-1971\|5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide\|5-Chloro-2-fluoro-4-(((1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl)oxy)-N-(pyrimidin-4-yl)benzenesulfonamide\|
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	DS-1971a is a potent, selective, and orally active inhibitor of NaV1.7 with IC50 of 22.8 nM and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Na v1.7
Product Description	Information DS-1971a is a potent, selective, and orally active inhibitor of NaV1.7 with IC50 of 22.8 nM and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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SCN2A Tclin Sodium channel protein type 2 subunit alpha 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN5A Tclin Sodium channel protein type 5 subunit alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN10A Tclin Sodium channel protein type 10 subunit alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN3A Tclin Sodium channel protein type 3 subunit alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN9A Tclin Sodium channel protein type 9 subunit alpha 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN4A Tclin Sodium channel protein type 4 subunit alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN1A Tclin Sodium channel protein type 1 subunit alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN8A Tclin Sodium channel protein type 8 subunit alpha 1 Activities

Discover Target: SCN8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide
INCHI	InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1
InChi Key	OJKONCJPCULNOW-DYVFJYSZSA-N
Canonical SMILES	CN1C(=CC=N1)C2CCCCC2OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=NC=NC=C4)F
Isomeric SMILES	CN1C(=CC=N1)[C@H]2CCCC[C@@H]2OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=NC=NC=C4)F
Alternate CAS	1450595-86-4
PubChem CID	71711862
MeSH Entry Terms	5-chloro-2-fluoro-4-((2-(1-methyl-1H-pyrazol-5-yl)-cyclohexyl)oxy)-N-(pyrimidin-4-yl)benzene-1-sulfonamide;DS-1971a
Molecular Weight	465.93

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
B2426557	Certificate of Analysis	Jan 18, 2024	D412696
B2426558	Certificate of Analysis	Jan 18, 2024	D412696
B2426559	Certificate of Analysis	Jan 18, 2024	D412696
B2426611	Certificate of Analysis	Jan 18, 2024	D412696
B2426612	Certificate of Analysis	Jan 18, 2024	D412696
B2426613	Certificate of Analysis	Jan 18, 2024	D412696
B2426614	Certificate of Analysis	Jan 18, 2024	D412696
B2426615	Certificate of Analysis	Jan 18, 2024	D412696
B2426616	Certificate of Analysis	Jan 18, 2024	D412696
B2426617	Certificate of Analysis	Jan 18, 2024	D412696

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