DS45500853 - 98%, high purity , CAS No.2735803-28-6

Item Number

D646653

Grouped product items
SKU	Size	Availability	Price
D646653-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
D646653-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
D646653-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
D646653-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90

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Basic Description

Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	DS45500853 is an estrogen-related receptor α ( ERRα ) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC 50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM) In Vitro DS45500853 (compound 5c; 0.002, 0.006, 0.017, 0.051, 0.015, 0.046, 1.4, 4.2, 12.5 μg/mL; 18 h) inhibits the transcriptional activity of full-length ERRα in MG63 cells with an EC 50 of 5.4 μM. DS45500853 binds in the ligand-binding pocket (LBP) of the ERRα LBD as inverse agonist II. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:ERRα

Canonical SMILES

CC(C1=CC=C(OC2=CC=C(O)C(C(C)(C)C)=C2)C=C1)=O

Molecular Weight

284.35

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Basic Description