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DSM421 , CAS No.D609990, Inhibitor of dihydroorotate dehydrogenase (quinone);Plasmodium falciparum dihydroorotate dehydrogenase

DSM421 , CAS No.D609990, Inhibitor of dihydroorotate dehydrogenase (quinone);Plasmodium falciparum dihydroorotate dehydrogenase

Item Number

D609990

Grouped product items
SKU	Size	Availability	Price	Qty
D609990-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609990-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of dihydroorotate dehydrogenase (quinone);Plasmodium falciparum dihydroorotate dehydrogenase

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
INCHI	InChI=1S/C14H11F5N6/c1-7-5-10(22-8-3-4-9(20-6-8)14(17,18)19)25-12(21-7)23-11(24-25)13(2,15)16/h3-6,22H,1-2H3
InChi Key	HDLFZCDEGAWEFX-UHFFFAOYSA-N
Canonical SMILES	Cc1cc(Nc2ccc(nc2)C(F)(F)F)n2c(n1)nc(n2)C(F)(F)C
Isomeric SMILES	CC1=NC2=NC(=NN2C(=C1)NC3=CN=C(C=C3)C(F)(F)F)C(C)(F)F
PubChem CID	122552662

PubChem CID	122552662
RCSB PDB Ligand	78Z

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1. Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh K, Tomchick DR, Manjalanagara K, Rudra KR et al.. (2016) A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.. ACS Infect Dis, 2 (12): (945-957). [PMID:27641613]
2. Lynch 3rd JJ, Rossignol E, Moehrle JJ, Van Vleet TR, Marsh KC, Parman T, Mirsalis J, Ottinger SE, Segreti JA, Rao M et al.. (2019) Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.. J Pharmacol Toxicol Methods, 99 (3): (106580). [PMID:31085318]

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