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DSM502 - ≥98%, high purity , CAS No.2426616-55-7, Plasmodium falciparum dihydroorotate dehydrogenase

  • Moligand™
  • ≥98%
Item Number
D609991
Grouped product items
SKUSizeAvailabilityPrice Qty
D609991-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
D609991-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609991-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$639.90
D609991-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,279.90

Basic Description

Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Mechanism of actionPlasmodium falciparum dihydroorotate dehydrogenase
Product Description

DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs

Associated Targets

DHODH Tclin Dihydroorotate dehydrogenase (quinone), mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Canonical SMILES O=C(C1=C(C)C(CC2=CC=C(C(F)(F)F)N=C2)=CN1)NC3CC3
Molecular Weight 323.31

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
H2420200Certificate of AnalysisMay 08, 2024 D609991
H2420201Certificate of AnalysisMay 08, 2024 D609991
H2420202Certificate of AnalysisMay 08, 2024 D609991
H2420203Certificate of AnalysisMay 08, 2024 D609991
H2420204Certificate of AnalysisMay 08, 2024 D609991
H2420205Certificate of AnalysisMay 08, 2024 D609991
H2420206Certificate of AnalysisMay 08, 2024 D609991
H2420215Certificate of AnalysisMay 08, 2024 D609991

Related Documents

References

1. Kokkonda S, Deng X, White KL, El Mazouni F, White J, Shackleford DM, Katneni K, Chiu FCK, Barker H, McLaren J et al..  (2020)  Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria..  J Med Chem,  63  (9): (4929-4956).  [PMID:32248693]

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