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DSR 6434 - ≥98%(HPLC), high purity , CAS No.1059070-10-8

≥98%(HPLC)

CAS#: 1059070-10-8
Formula: C₁₉H₂₈N₈O₂
Molecular Weight: 400.48
PubChem CID: 25071151

Item Number

D287770

Grouped product items
SKU	Size	Availability	Price
D287770-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$216.90
D287770-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$484.90
D287770-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$890.90
D287770-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,533.90
D287770-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,451.90

Potent TLR7 agonist

View related series

Toll-like Receptor (TLR)

Basic Description

Synonyms	1059070-10-8\|DSR-6434\|6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one\|DSR 6434\|8YBW739LJ0\|CHEMBL2315158\|6-amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8h-purin-8
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent TLR7 agonist (EC50= 7.2 nM). Activates several immune effector cellsin vitro. Suppresses metastasisin vivoand enhances efficacy of radiation therapy in a model of colorectal carcinoma.
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	Product description DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TLR7 Tclin Toll-like receptor 7 1 Activities

Discover Target: TLR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one
INCHI	InChI=1S/C19H28N8O2/c1-4-5-8-21-18-24-16(20)15-17(25-18)27(19(28)23-15)12-13-6-7-14(22-11-13)29-10-9-26(2)3/h6-7,11H,4-5,8-10,12H2,1-3H3,(H,23,28)(H3,20,21,24,25)
InChi Key	SSZHESNDOMBSRV-UHFFFAOYSA-N
Canonical SMILES	CCCCNC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CN=C(C=C3)OCCN(C)C)N
Isomeric SMILES	CCCCNC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CN=C(C=C3)OCCN(C)C)N
PubChem CID	25071151
Molecular Weight	400.48

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
A2419649	Certificate of Analysis	Jan 08, 2024	D287770
B2419648	Certificate of Analysis	Jan 08, 2024	D287770
B2419650	Certificate of Analysis	Jan 08, 2024	D287770
B2419651	Certificate of Analysis	Jan 08, 2024	D287770
B2419652	Certificate of Analysis	Jan 08, 2024	D287770
B2419653	Certificate of Analysis	Jan 08, 2024	D287770
B2419654	Certificate of Analysis	Jan 08, 2024	D287770
B2419655	Certificate of Analysis	Jan 08, 2024	D287770

Solubility

Solvent:1eq. HCl, Max Conc. mg/mL: 20.02, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 40.05, Max Conc. mM: 100

Sensitivity

light sensitive

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