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Duloxetine - ≥99%, high purity , CAS No.116539-59-4, Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Inhibitor of NET;Inhibitor of SERT
an inhibitor of ST and SLC6A2
Basic Description Synonyms duloxetine|116539-59-4|(S)-Duloxetine|Yentreve|(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine|LY 248686|HSDB 7368|LY248686|UNII-O5TNM5N07U|methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine|O5TNM5N07U|Duloxetine (INN)|CH Specifications & Purity Moligand™, ≥99% Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST, INHIBITOR Mechanism of action Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Inhibitor of NET;Inhibitor of SERT Product Description Duloxetine is an ST and SLC6A2 inhibitor (serotonin-norepinephrine reuptake inhibitor/SNRI).
Product Properties pKa pKa: 10.02 (Predicted) Ki Data ST: Ki= 0.5 nM (human); rat: Ki= 4.6 nM; SLC6A2: Ki= 5.97 nM (human); Histamine H3 receptor: Ki>5 μM (human)
Names and Identifiers IUPAC Name (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine INCHI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 InChi Key ZEUITGRIYCTCEM-KRWDZBQOSA-N Canonical SMILES CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32 Isomeric SMILES CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32 PubChem CID 60835 Molecular Weight 297.42 Beilstein 4297128
Chemical and Physical Properties Solubility Soluble in water (slightly).Soluble in DMSO Sensitivity Light sensitive Refractive Index n20D1.63 (Predicted) Specific Rotation[α] α20D+120.5°±4.5°, c = 1 in methanol Boil Point(°C) 466.2° C at 760 mmHg Melt Point(°C) 156.99° C (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Warning Hazard Statements H351: Suspected of causing cancer
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
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G2301056