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Dynasore - ≥98%, high purity , CAS No.304448-55-3

  • ≥98%
Item Number
D125461
Grouped product items
SKUSizeAvailabilityPrice Qty
D125461-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$56.90
D125461-10mg
10mg
In stock
$88.90
D125461-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$204.90
D125461-50mg
50mg
In stock
$325.90
D125461-250mg
250mg
In stock
$1,467.90
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Cell-permeable dynamin inhibitor

View related series
Bioactive small molecule

Basic Description

SynonymsDynasore|304448-55-3|Dynamin Inhibitor I, Dynasore|CHEMBL1209885|N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide|N'-[(3,4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide|N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxy
Specifications & Purity≥98%
Biochemical and Physiological MechanismsDynasore is a non-competitive, cell-permeable semicarbazone compound inhibitor of Dynamin I and Dynamin II. Members of the Dynamin family, including Dynamin I, Dynamin II and Dynamin III, are GTPase, microtubule-associated proteins which are involved in e
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase
An inhibitor of Dynamin I and Dynamin II

Associated Targets

DNM2 Tchem Dynamin-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DNM1 Tbio Dynamin-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDC42SE1 Tdark CDC42 small effector protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide
INCHI InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChi Key SYNDQCRDGGCQRZ-VXLYETTFSA-N
Canonical SMILES C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O
Isomeric SMILES C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
PubChem CID 135533054
Molecular Weight 322.31

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6 results found

Lot NumberCertificate TypeDateItem
I2203163Certificate of AnalysisJun 14, 2024 D125461
I2203164Certificate of AnalysisJun 14, 2024 D125461
D2313828Certificate of AnalysisJun 24, 2022 D125461
I2203162Certificate of AnalysisJun 24, 2022 D125461
L2322050Certificate of AnalysisJun 24, 2022 D125461
C2225027Certificate of AnalysisMay 11, 2022 D125461

Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mM), and ethanol (5 mM). Insoluble in water
SensitivityHeat Sensitive；light sensitive

Related Documents

 SDS

 Specification Sheet

References

1. Lu Q et al..  (2018)  A novel probe to assess cytosolic entry of exogenous proteins..  Nat Commun,  9  (3104).  [PMID:30082832]
2. Kang Y et al..  (2014)  A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2..  J Biol Chem,  289  (42): (29350-64).  [PMID:25190809]
3. Tanaka H et al..  (2022)  Aberrant autophagy in lysosomal storage disorders marked by a lysosomal SNARE protein shortage due to suppression of endocytosis..  J Inherit Metab Dis,  45  (6): (1191-1202).  [PMID:36102069]
4. Morinaga T et al..  (2014)  Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment..  J Biol Chem,  289  (38): (26327-43).  [PMID:25104351]
5. Chen Y et al..  (2022)  Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance..  EMBO Rep,  23  (3): (e53373).  [PMID:34994492]
6. Losier TT et al..  (2019)  AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles..  Cell Rep,  26  (8): (2150-2165.e5).  [PMID:30784596]
7. Liu X et al..  (2019)  AMPK-mediated degradation of Nav1.5 through autophagy..  FASEB J,  33  (4): (5366-5376).  [PMID:30759345]
8. Mancuso RV et al..  (2020)  Anti-aLß2 antibodies reveal novel endocytotic cross-modulatory functionality..  Br J Pharmacol,  177  (12): (2696-2711).  [PMID:31985813]
9. Belaidi AA et al..  (2022)  Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy..  Mol Psychiatry,      [PMID:35484240]
10. Lynn KS et al..  (2021)  Asymmetric distribution of dynamin-2 and ß-catenin relative to tight junction spikes in alveolar epithelial cells..  Tissue Barriers,    (1929786).  [PMID:34107845]
11. Medeiros AT et al..  (2017)  a-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling..  Front Cell Neurosci,  11  (388).  [PMID:29321725]
12. McCluskey A et al..  (2013)  Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis..  Traffic,      [PMID:24025110]
13. Ford C et al..  (2018)  Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry..  PLoS Pathog,  14  (5): (e1007051).  [PMID:29727463]
14. Ganguly A et al..  (2021)  Clathrin packets move in slow axonal transport and deliver functional payloads to synapses..  Neuron,  109  (18): (2884-2901.e7).  [PMID:34534453]
15. Tan X et al..  (2018)  Clathrin-mediated endocytosis regulates fMLP-mediated neutrophil polarization..  Heliyon,  4  (9): (e00819).  [PMID:30263974]
16. Tecedor L et al..  (2013)  CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells..  J Neurosci,  33  (46): (18065-79).  [PMID:24227717]
17. Ivashko-Pachima Y & Gozes I.  (2020)  Deciphering the Enigma: NAP (CP201) the Active ADNP Drug Candidate Enters Cells by Dynamin-Associated Endocytosis..  J Mol Neurosci,  70  (7): (993-998).  [PMID:32588400]
18. Reyes-Alcaraz A et al..  (2018)  Conformational signatures in ß-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor..  Commun Biol,  1  (128).  [PMID:30272007]
19. Sosna J et al..  (2016)  Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells..  Mol Cell Biol,  36  (20): (2626-44).  [PMID:27528614]
20. Phan-Everson T et al..  (2021)  Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport..  Dev Cell,  56  (13): (1930-1944.e5).  [PMID:34051144]
21. Yoshida N et al..  (2011)  CXCR4 expression on activated B cells is downregulated by CD63 and IL-21..  J Immunol,  186  (5): (2800-8).  [PMID:21270405]
22. Douthitt HL et al..  (2011)  Dynasore, an inhibitor of dynamin, increases the probability of transmitter release..  Neuroscience,  172  (187-95).  [PMID:21056636]
23. Ridge LA et al..  (2021)  Dual role for CXCL12 signaling in semilunar valve development..  Cell Rep,  36  (8): (109610).  [PMID:34433040]
24. Shah N et al..  (2018)  Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers..  Biochim Biophys Acta,  1864  (8): (2610-2622).  [PMID:29684588]
25. Chiang CF et al..  (2016)  Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells..  PLoS One,  11  (10): (e0164768).  [PMID:27780263]
26. Shi BJ et al..  (2016)  Entry of Classical Swine Fever Virus into PK-15 Cells via a pH-, Dynamin-, and Cholesterol-Dependent, Clathrin-Mediated Endocytic Pathway That Requires Rab5 and Rab7..  J Virol,  90  (20): (9194-208).  [PMID:27489278]
27. Garay C et al..  (2015)  Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis..  Mol Biol Cell,  26  (19): (3504-19).  [PMID:26246598]
28. Li BT et al..  (2020)  HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers..  Cancer Discov,  10  (5): (674-687).  [PMID:32213539]
29. Chattergoon MA et al..  (2014)  HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon..  PLoS Pathog,  10  (5): (e1004082).  [PMID:24788318]
30. Hyun J et al..  (2019)  HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells..  PLoS Pathog,  15  (7): (e1007883).  [PMID:31260499]
31. de la Vega M et al..  (2011)  Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion..  Retrovirology,  8  (99).  [PMID:22145853]
32. Krzyzaniak MA et al..  (2013)  Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein..  PLoS Pathog,  9  (4): (e1003309).  [PMID:23593008]
33. King AJ et al..  (2018)  Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability..  Sci Transl Med,  10  (456):   [PMID:30158152]
34. Lum M et al..  (2013)  Impact of dynasore an inhibitor of dynamin II on Shigella flexneri infection..  PLoS One,  8  (12): (e84975).  [PMID:24367704]
35. Wen X et al..  (2017)  Kiss-and-Run Is a Significant Contributor to Synaptic Exocytosis and Endocytosis in Photoreceptors..  Front Cell Neurosci,  11  (286).  [PMID:28979188]
36. Park DJ et al..  (2020)  Improvement of stem cell-derived exosome release efficiency by surface-modified nanoparticles..  J Nanobiotechnology,  18  (178).  [PMID:33287848]
37. Oppliger J et al..  (2016)  Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis..  J Virol,  90  (14): (6412-29).  [PMID:27147735]
38. Calafate S et al..  (2016)  Loss of Bin1 Promotes the Propagation of Tau Pathology..  Cell Rep,  17  (4): (931-940).  [PMID:27760323]
39. Li Z et al..  (2021)  Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes..  Commun Biol,  4  (1076).  [PMID:34521989]
40. Evans MD et al..  (2017)  Myosin II activity is required for structural plasticity at the axon initial segment..  Eur J Neurosci,  46  (2): (1751-1757).  [PMID:28452088]
41. Basquin C et al..  (2015)  Membrane protrusion powers clathrin-independent endocytosis of interleukin-2 receptor..  EMBO J,  34  (16): (2147-61).  [PMID:26124312]
42. Frühbeis C et al..  (2013)  Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication..  PLoS Biol,  11  (7): (e1001604).  [PMID:23874151]
43. Zhang YN et al..  (2018)  Rab5, Rab7, and Rab11 Are Required for Caveola-Dependent Endocytosis of Classical Swine Fever Virus in Porcine Alveolar Macrophages..  J Virol,  92  (15):   [PMID:29769350]
44. Van Hook MJ & Thoreson WB.  (2012)  Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina..  J Neurosci,  32  (50): (18112-23).  [PMID:23238726]
45. Aravamudhan P et al..  (2020)  Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons..  PLoS Pathog,  16  (2): (e1008380).  [PMID:32109948]
46. Watson J et al..  (2022)  Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival..  Nat Commun,  13  (6589).  [PMID:36329028]
47. Wagner S et al..  (2012)  The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms oligomers and traffics between the plasma membrane and different intracellular compartments..  Arch Virol,  157  (5): (935-49).  [PMID:22327422]
48. Zhang W et al..  (2013)  Transient fusion and selective secretion of vesicle proteins in Phytophthora nicotianae zoospores..  PeerJ,  1  (e221).  [PMID:24392285]

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