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e-6005 - 96%, high purity , Phosphodiesterase 4 inhibitor, CAS No.947620-48-6, Phosphodiesterase 4 inhibitor

e-6005 - 96%, high purity , Phosphodiesterase 4 inhibitor, CAS No.947620-48-6, Phosphodiesterase 4 inhibitor

Item Number

E178447

Grouped product items
SKU	Size	Availability	Price
E178447-2mg	2mg	In stock	$62.90
E178447-5mg	5mg	In stock	$129.90
E178447-10mg	10mg	In stock	$195.90
E178447-25mg	25mg	In stock	$441.90
E178447-50mg	50mg	In stock	$639.90
E178447-100mg	100mg	In stock	$1,031.90

Basic Description

Synonyms	Lotamilast\|947620-48-6\|E6005\|E-6005\|RVT-501\|Methyl 4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate\|Lotamilast [USAN]\|TO043KKB9C\|Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate\|(Methyl 4-((
Specifications & Purity	≥96%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Phosphodiesterase 4 inhibitor
Product Description	Lotamilast (RVT-501, E6005) is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50 of 2.8 nM.

ALogP	4.2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	methyl 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate
INCHI	InChI=1S/C26H24N4O5/c1-27-26-29-20-14-22(34-3)21(33-2)13-19(20)23(30-26)17-6-5-7-18(12-17)28-24(31)15-8-10-16(11-9-15)25(32)35-4/h5-14H,1-4H3,(H,28,31)(H,27,29,30)
InChi Key	BBTFKAOFCSOZMB-UHFFFAOYSA-N
Canonical SMILES	CNC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC=C3)NC(=O)C4=CC=C(C=C4)C(=O)OC)OC)OC
Isomeric SMILES	CNC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC=C3)NC(=O)C4=CC=C(C=C4)C(=O)OC)OC)OC
PubChem CID	24864553
Molecular Weight	472.501

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6 results found

Lot Number	Certificate Type	Date	Item
K2215476	Certificate of Analysis	Aug 12, 2022	E178447
K2215477	Certificate of Analysis	Aug 12, 2022	E178447
K2215478	Certificate of Analysis	Aug 12, 2022	E178447
K2215479	Certificate of Analysis	Aug 12, 2022	E178447
K2215480	Certificate of Analysis	Aug 12, 2022	E178447
K2215481	Certificate of Analysis	Aug 12, 2022	E178447

Solubility	DMSO : ≥ 100 mg/mL (211.64 mM)

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