(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic
In Vitro
(E)-Akt inhibitor-IV (compound 7) exhibits average GI 20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells). (E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI 20 doses. MCE has not independently confirmed the accuracy of these methods. They are for reference only.