(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate - ≥83.0%, high purity , CAS No.1191901-33-3

Item Number

E486554

• Synonyms: (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate | SCHEMBL1300090 | BP-22417 | 1191901-33-3 | TCO-NHS | Carbonic acid, (4E)-4-cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester | Tco-N-hydroxysuccinimidyl carbonate | TCO-NHS ester | 2249928-24-1 | OUGQJ
• Specifications & Purity: ≥83%
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads

Product Description

Description

Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate may be used in the synthesis of vancomycin-TCO that can bind to the cell wall of gram-positive bacteria, which can subsequently react with tetrazine (Tz) decorated magneto-fluorescent nanoparticles orthogonally. This bioorthogonal labeling method is useful for the detection of gram-positive bacteria.