(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate - ≥83.0%, high purity , CAS No.1191901-33-3

Item Number

E486554

• Synonyms: TCO-NHS ester|1191901-33-3|TCO-NHS|(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate|MFCD24386372|(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate|(E)-cyclooct-4-enyl 2,5-dioxopyrrolidin-1-yl carbonate|TCO-NHS Ester (equatorial)|2BX65M7XV6
• Specifications & Purity: ≥83.0%
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads

Product Description

Description

Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate may be used in the synthesis of vancomycin-TCO that can bind to the cell wall of gram-positive bacteria, which can subsequently react with tetrazine (Tz) decorated magneto-fluorescent nanoparticles orthogonally. This bioorthogonal labeling method is useful for the detection of gram-positive bacteria.