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EAI045 - 95%, high purity , CAS No.1942114-09-1, Allosteric modulator of epidermal growth factor receptor
Basic Description Synonyms 2H-Isoindole-2-acetamide,α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-；(Z)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetimidic acid Specifications & Purity Moligand™, ≥95% Biochemical and Physiological Mechanisms EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants but spares the wild-type receptor. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of epidermal growth factor receptor
Names and Identifiers IUPAC Name 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide INCHI InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25) InChi Key YTUFHOKUFOQRDF-UHFFFAOYSA-N Canonical SMILES C1C2=CC=CC=C2C(=O)N1C(C3=C(C=CC(=C3)F)O)C(=O)NC4=NC=CS4 Isomeric SMILES C1C2=CC=CC=C2C(=O)N1C(C3=C(C=CC(=C3)F)O)C(=O)NC4=NC=CS4 PubChem CID 121231412 MeSH Entry Terms 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide;EAI045 Molecular Weight 383.4
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 76 mg/mL (198.22 mM); Water: Insoluble; Ethanol: Insoluble;
References 1. Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H et al. . (2016) Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.. Nature, 534 (7605): (129-32). [PMID:27251290 ]
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B2313231