JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Click Here for 5% Off Your First Aladdin Purchase!

྾

Home
Applications
Targets
Kinases
TK:Tyrosine kinase
EAI045 , CAS No.E610049, Allosteric modulator of epidermal growth factor receptor

Skip to the end of the images gallery

Skip to the beginning of the images gallery

EAI045 , CAS No.E610049, Allosteric modulator of epidermal growth factor receptor

Moligand™

PubChem CID: 121231412

Item Number

E610049

Grouped product items
SKU	Size	Availability	Price	Qty
E610049-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
E610049-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

epidermal growth factor receptor Allosteric modulator

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of epidermal growth factor receptor

Associated Targets

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
INCHI	InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)
InChi Key	YTUFHOKUFOQRDF-UHFFFAOYSA-N
Canonical SMILES	Fc1ccc(c(c1)C(N1Cc2c(C1=O)cccc2)C(=O)Nc1nccs1)O
Isomeric SMILES	C1C2=CC=CC=C2C(=O)N1C(C3=C(C=CC(=C3)F)O)C(=O)NC4=NC=CS4
PubChem CID	121231412

Database links

PubChem CID	121231412

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H et al.. (2016) Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.. Nature, 534 (7605): (129-32). [PMID:27251290]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.