EBI-2511 - 98%, high purity , CAS No.2098546-05-3, Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

Item Number

E414124

• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC50 of 4 nM for EZH2(A667G).
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

Product Description

Information

EBI-2511 EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC50 of 4 nM for EZH2(A667G).

Targets

EZH2(A667G) (Cell-free assay) 4 nM

In vivo

In in vivo experiments, rats are administrated with dosages of 5 mg/kg EBI-2511 (p.o.) and 0.5 mg/kg EBI-2511 (i.v.). Mice are administrated with dosages of 10 mg/kg p.o. and 1.0 mg/kg i.v. For i.v. administration, the clearance of EBI-2511 is modest with CLz/F of 26 and 32 mL/min/kg in rats and mice, respectively. After a single 5 and 10 mg/kg oral dose of a CMC-Na suspension of EBI-2511 to rats and mice, its AUC_0‑t reaches 239 and 774 ng/mL·h with oral bioavailability of 9% and 16%, respectively. plasma protein binding of EBI-2511 in human, rat, and mouse are 93.9%, 94.0%, and 92.7%, respectively.

Cell Research(from reference)

Cell lines：Pfeiffer cells 

Incubation Time：5 days