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(-)-Eburnamonine - ≥99%, high purity , CAS No.4880-88-0, Allosteric modulator of M 1 receptor;Allosteric modulator of M 2 receptor;Allosteric modulator of M 3 receptor;Allosteric modulator of M 4 receptor

  • Moligand™
  • ≥99%
Item Number
E348350
Grouped product items
SKUSizeAvailabilityPrice Qty
E348350-100mg
100mg
In stock
$94.90
E348350-250mg
250mg
In stock
$213.90
E348350-1g
1g
In stock
$769.90

a vasodilator that also acts as a cerebral metabolic stimulant

Basic Description

SynonymsVinburnine|(-)-Eburnamonine|4880-88-0|Vincamone|eburnamonine|l-Eburnamonine|Eburnal|Eburnamonine (-)|Vinburnine [INN]|Vincanorine|DL-Eburnamonine|Eburnamonine (-)-form|(+/-)-Vincamone|(+/-)-Eburnamonine|Vinburnine, (+/-)-|CH-846|Eburnamonine (+/-)-form [M
Specifications & PurityMoligand™, ≥99%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of M 1 receptor;Allosteric modulator of M 2 receptor;Allosteric modulator of M 3 receptor;Allosteric modulator of M 4 receptor
Product Description

(-)-Eburnamonine is a vasodilator that also acts as a cerebral metabolic stimulant. The compound can protect the cerebral of mice exposed to potassium cyanide intoxication. Studies show that (-)-Eburnamonine increases the affinity of acetylcholine on the M2 and M4 receptors, as well as augment the affinity of carbachol , bethanechol, furmethide, methylfurmethide, pentylthio-TZTP, pilocarpine, oxotremorine and oxotremorine-M on the M2 receptors. Research also shows that (-)-Eburnamonine has antihypoxic effects.

Product Properties

pKapKa: 8.13

Associated Targets

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATXN2 Tbio Ataxin-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APOBEC3G Tchem DNA dC->dU-editing enzyme APOBEC-3G 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one
INCHI InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1
InChi Key WYJAPUKIYAZSEM-MOPGFXCFSA-N
Canonical SMILES CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=O)C2
Isomeric SMILES CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4C(=O)C2
WGK Germany 2
RTECS YY8575570
PubChem CID 71203
Molecular Weight 294.39
Beilstein 4706903

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
K2209561Certificate of AnalysisJul 19, 2022 E348350
K2209562Certificate of AnalysisJul 19, 2022 E348350
K2209570Certificate of AnalysisJul 19, 2022 E348350

Chemical and Physical Properties

SolubilitySoluble in chloroform.
Refractive Indexn20D1.72 (Predicted)
Specific Rotation[α]α20/D -94.5°±2°, c = 1 in chloroform
Boil Point(°C)441.88° C at 760 mmHg (Predicted)
Melt Point(°C)174-176°C

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P319:Get medical help if you feel unwell.

WGK Germany 2
RTECS YY8575570
Merck Index 3.00486111111111

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