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Echinacoside - 98%, high purity , CAS No.82854-37-3

  • ≥98%
Item Number
B137910
Grouped product items
SKUSizeAvailabilityPrice Qty
B137910-5mg
5mg
In stock
$48.90
B137910-10mg
10mg
In stock
$78.90
B137910-25mg
25mg
In stock
$177.90
B137910-50mg
50mg
In stock
$236.90
B137910-100mg
100mg
In stock
$426.90
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Natural product

Basic Description

SynonymsEchinacoside|82854-37-3|CHEBI:4745|I04O1DT48T|[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E
Specifications & Purity≥98%
Biochemical and Physiological MechanismsCaffeic acid glycoside found in herbal medicine. Potential therapeutic for Parkinson′s disease. Echinacoside elicits neuroprotective properties against neurological disorders and on tumor necrosis factor-alpha (TNFα)-induced apoptosis in human neuroblasto
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
Product Description

Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilative ones. Echinacoside (ECH) is a natural secondary metabolite, a phenylethanoid glycoside (PhG) found in the roots and stems of many plants. It is a water-soluble compound. Echinacoside was first isolated from the roots of Echinacea angustifolia (coneflower). It can also be sourced from other medicinal plants such as Echinacea purpurea (purple coneflower) and Cistanche salsa.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CXCL8 Tchem Interleukin-8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
INCHI InChI=1S/C35H46O20/c1-14-24(42)26(44)29(47)35(51-14)55-32-30(48)34(49-9-8-16-3-6-18(38)20(40)11-16)53-22(13-50-33-28(46)27(45)25(43)21(12-36)52-33)31(32)54-23(41)7-4-15-2-5-17(37)19(39)10-15/h2-7,10-11,14,21-22,24-40,42-48H,8-9,12-13H2,1H3/b7-4+/t14-,21+,22+,24-,25+,26+,27-,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1
InChi Key FSBUXLDOLNLABB-ISAKITKMSA-N
Canonical SMILES CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@H]2OC(=O)/C=C/C3=CC(=C(C=C3)O)O)CO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O
PubChem CID 5281771
Molecular Weight 786.73

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14 results found

Lot NumberCertificate TypeDateItem
F2419161Certificate of AnalysisJun 07, 2024 B137910
F2419171Certificate of AnalysisJun 07, 2024 B137910
K2314285Certificate of AnalysisOct 20, 2023 B137910
K2314286Certificate of AnalysisOct 20, 2023 B137910
K2314287Certificate of AnalysisOct 20, 2023 B137910
K2314288Certificate of AnalysisOct 20, 2023 B137910
L2201560Certificate of AnalysisSep 27, 2022 B137910
L2201561Certificate of AnalysisSep 27, 2022 B137910
L2201563Certificate of AnalysisSep 27, 2022 B137910
C2205231Certificate of AnalysisMar 12, 2022 B137910
C2205268Certificate of AnalysisMar 12, 2022 B137910
C2205209Certificate of AnalysisMar 11, 2022 B137910
C2205233Certificate of AnalysisMar 11, 2022 B137910
C2205234Certificate of AnalysisMar 11, 2022 B137910

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Related Documents

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 Specification Sheet

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  3. Echinacoside - analytical standard,≥98%, used for , CAS No. 82854-37-3, by Aladdin Scientific
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References

1. Tai-Xin Yang,Yue-Xia Lu,Xi-Huan Zhang,Jing-Zhu Cai,Yu-Xin Zhao.  (2008-03-01)  [Inoculation experiments of Cistanche tubulosa on 8 introduced Tamarix species]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  32  ((20)): (2107-2109).  [PMID:18306738]
2. Tai-Xin Yang,Xi-Huan Zhang,Jing-Zhu Cai.  (2008-03-15)  [Study on secondary metabolic organ of echinacoside in herbs of Cistanche tubulosa]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  32  ((24)): (2591-2594).  [PMID:18338593]
3. Cunqin Jia,Haiming Shi,Wei Jin,Ke Zhang,Yong Jiang,Mingbo Zhao,Pengfei Tu.  (2008-11-22)  Metabolism of echinacoside, a good antioxidant, in rats: isolation and identification of its biliary metabolites..  Drug metabolism and disposition: the biological fate of chemicals,  37  ((2)): (431-438).  [PMID:19022941]
4. Hao Yang,Guangji Wang,Haiping Hao,Pengfei Tu,Yong Jiang,Qiong Wang,Yan Zhang,Chaonan Zheng,Yuxin Wang,Liang Dai.  (2009-03-12)  A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of echinacoside and its pharmacokinetic application in rats..  Biomedical chromatography : BMC,  23  ((6)): (630-637).  [PMID:19277965]
5. Wenjun He,Taihui Fang,Pengfei Tu.  (2009-05-23)  [Research progress on pharmacological activities of echinacoside]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  34  ((4)): (476-479).  [PMID:19459316]
6. Wen-Jun He,Tai-Hui Fang,Xu Ma,Ke Zhang,Zhi-Zhong Ma,Peng-Fei Tu.  (2009-05-27)  Echinacoside elicits endothelium-dependent relaxation in rat aortic rings via an NO-cGMP pathway..  Planta medica,  75  ((13)): (1400-1404).  [PMID:19468974]
7. Jian-jun Lv,Gao-sheng Hu,Jing-kui Li,Jing-ming Jia.  (2009-06-10)  [Effects of precursor feeding and fungal elicitors on secondary metabolits in cell suspension culture of Cistanche deserticola]..  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,  32  ((2)): (171-173).  [PMID:19504954]
8. Rong Kuang,Yiguo Sun,Wei Yuan,Li Lei,Xiaoxiang Zheng.  (2009-06-24)  Protective effects of echinacoside, one of the phenylethanoid glycosides, on H(2)O(2)-induced cytotoxicity in PC12 cells..  Planta medica,  75  ((14)): (1499-1504).  [PMID:19548189]
9. Parida Yamada,Rieko Iijima,Junkyu Han,Hideyuki Shigemori,Shinichi Yokota,Hiroko Isoda.  (2010-04-01)  Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells..  Planta medica,  76  ((14)): (1512-1518).  [PMID:20354949]
10. Jun Xie,Jun Deng,Feng Tan,Jing Su.  (2010-09-03)  Separation and purification of echinacoside from Penstemon barbatus (Can.) Roth by recycling high-speed counter-current chromatography..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  878  ((28)): (2665-2668).  [PMID:20810327]
11. Shu-Yan Zhao,Xiu-Yan He,Bao-Guo Jia,Qing-Yun Peng,Xin Liu.  (2011-04-02)  Production of acteoside from Cistanche tubulosa by β-glucosidase..  Pakistan journal of pharmaceutical sciences,  24  ((2)): (135-141).  [PMID:21454161]
12. David S Senchina,Jennifer H Strauch,Griffin B Hoffmann,Nisarg B Shah,Brad K Laflen,Breanna L Dumke,Chinh T Dao,Amila S Dias,M Ann Perera.  (2011-04-09)  Phytochemical and immunomodulatory properties of an Echinacea laevigata (Asteraceae) tincture..  Journal of alternative and complementary medicine (New York, N.Y.),  17  ((4)): (375-377).  [PMID:21473700]
13. Li Li Wei,Hong Chen,Yong Jiang,Peng Fei Tu,Ming Zhong,Juan Du,Fei Liu,Lei Wang,Chun Yang Liu.  (2012-09-25)  Effects of echinacoside on histio-central levels of active mass in middle cerebral artery occlusion rats..  Biomedical and environmental sciences : BES,  25  ((2)): (238-244).  [PMID:22998833]
14. Fei Li,Xiaolin Yang,Yanan Yang,Changrun Guo,Chunfeng Zhang,Zhonglin Yang,Ping Li.  (2013-02-23)  Antiosteoporotic activity of echinacoside in ovariectomized rats..  Phytomedicine : international journal of phytotherapy and phytopharmacology,  20  ((6)): (549-557).  [PMID:23428402]
15. Dong-Mi Shin,Kyeong-Mi Choi,Youn-Sun Lee,Wonkyun Kim,Kyong-Oh Shin,Seikwan Oh,Jae-Chul Jung,Mi Kyeong Lee,Yong-Moon Lee,Jin Tae Hong,Yeo-Pyo Yun,Hwan-Soo Yoo.  (2013-10-03)  Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells..  Archives of pharmacal research,  37  ((6)): (803-812).  [PMID:24085629]
16. Ivan Kováč,Ján Ďurkáč,Martin Hollý,Katarína Jakubčová,Vlasta Peržeľová,Pavel Mučaji,Emil Švajdlenka,František Sabol,Jaroslav Legáth,Jozef Belák,Karel Smetana,Peter Gál.  (2014-09-23)  Plantago lanceolata\u2005L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds..  The Journal of pharmacy and pharmacology,  67  ((1)): (117-125).  [PMID:25244603]
17. Monika E Czerwińska,Marlena Ziarek,Agnieszka Bazylko,Ewa Osińska,Anna K Kiss.  (2015-02-20)  Quantitative Determination of Secoiridoids and Phenylpropanoids in Different Extracts of Ligustrum Vulgare L. Leaves by a Validated HPTLC-Photodensitometry Method..  Phytochemical analysis : PCA,  26  ((4)): (253-260).  [PMID:25693970]
18. Liwei Dong,Hongge Wang,Jiajing Niu,Mingwei Zou,Nuoting Wu,Debin Yu,Ye Wang,Zhihua Zou.  (2015-12-18)  Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1..  OncoTargets and therapy,  8  (3649-3664).  [PMID:26677335]
19. Min Chen,Guang-Hong Cui,Su-Ping Xiao,Shu-Fang Lin,Zhi-Gang Wu,Lu-Qi Huang.  (2009-01-27)  [Preliminary study on variation pattern of Cistanche deserticola]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  33  ((19)): (2179-2181).  [PMID:19166000]
20. Yuxin Wang,Haiping Hao,Guangji Wang,Pengfei Tu,Yong Jiang,Yan Liang,Liang Dai,Hao Yang,Li Lai,Chaonan Zheng,Qiong Wang,Nan Cui,Yitong Liu.  (2009-10-20)  An approach to identifying sequential metabolites of a typical phenylethanoid glycoside, echinacoside, based on liquid chromatography-ion trap-time of flight mass spectrometry analysis..  Talanta,  80  ((2)): (572-580).  [PMID:19836522]
21. Hong Xie,Hui Zhu,Cong Cheng,Yu Liang,Zhao Wang.  (2010-01-27)  Echinacoside retards cellular senescence of human fibroblastic cells MRC-5..  Die Pharmazie,  64  ((11)): (752-754).  [PMID:20099521]
22. Rong Kuang,Yiguo Sun,Xiaoxiang Zheng.  (2010-05-04)  Suppression of nitric oxide implicated in the protective effect of echinacoside on H2O2-induced PC12 cell injury..  Natural product communications,  5  ((4)): (571-574).  [PMID:20433075]
23. Gao Sheng Hu,Yeon Jae Hur,Jing Ming Jia,Jai Heon Lee,Young Soo Chung,Young Byung Yi,Dae Jin Yun,Soon Ki Park,Doh Hoon Kim.  (2011-01-19)  Effects of 2-aminoindan-2-phosphonic acid treatment on the accumulation of salidroside and four phenylethanoid glycosides in suspension cell culture of Cistanche deserticola..  Plant cell reports,  30  ((4)): (665-674).  [PMID:21243361]
24. Pavel Mučaji,Anna Záhradníková,Lýdia Bezáková,Mária Cupáková,Drahomíra Rauová,Milan Nagy.  (2011-10-01)  HPLC determination of antilipoxygenase activity of a water infusion of Ligustrum vulgare L. leaves and some of its constituents..  Molecules (Basel, Switzerland),  16  ((10)): (8198-8208).  [PMID:21959294]
25. Yamin Jia,Qiunong Guan,Yuhai Guo,Caigan Du.  (2011-12-22)  Echinacoside stimulates cell proliferation and prevents cell apoptosis in intestinal epithelial MODE-K cells by up-regulation of transforming growth factor-β1 expression..  Journal of pharmacological sciences,  118  ((1)): (99-108).  [PMID:22186624]
26. Fei Li,Yanan Yang,Panpan Zhu,Weina Chen,Dongli Qi,Xiupu Shi,Chunfeng Zhang,Zhonglin Yang,Ping Li.  (2012-09-07)  Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells..  Fitoterapia,  83  ((8)): (1443-1450).  [PMID:22951288]
27. Min Zhu,Chuanzhen Lu,Wenwei Li.  (2012-11-30)  Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone..  Journal of neurochemistry,  124  ((4)): (571-580).  [PMID:23189969]
28. Toshio Morikawa,Kiyofumi Ninomiya,Mio Imamura,Junji Akaki,Shota Fujikura,Yingni Pan,Dan Yuan,Masayuki Yoshikawa,Xiaoguang Jia,Zheng Li,Osamu Muraoka.  (2014-04-22)  Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice..  Journal of natural medicines,  68  ((3)): (561-566).  [PMID:24748124]
29. Liwei Dong,Debin Yu,Nuoting Wu,Hongge Wang,Jiajing Niu,Ye Wang,Zhihua Zou.  (2015-07-02)  Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages..  International journal of molecular sciences,  16  ((7)): (14655-14668).  [PMID:26132569]

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