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Econazole - 97%, high purity , CAS No.27220-47-9, Channel blocker of TRPM2;Channel blocker of TRPV5
Basic Description
| Synonyms | econazole|27220-47-9|Ecostatin|Econazolum|Econazol|(+-)-Econazole|Spectazole|1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole|UNII-6Z1Y2V4A7M|NSC 187789|NSC-187789|6Z1Y2V4A7M|CCRIS 9032|Econazol [INN-Spanish]|EINECS 248-341-6|BRN 09641 |
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| Specifications & Purity | Moligand™, ≥97% |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | CHANNEL BLOCKER |
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| Mechanism of action | Channel blocker of TRPM2;Channel blocker of TRPV5 |
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| Product Description | Econazole is an antifungal compound of the imidazole class.
Application Econazole is a broad spectrum antimycotic with some action against Gram positive bacteria.
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Product Properties
| pKa | pKₐ: 6.68 (Predicted) |
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| Ki Data | Serotonin transporter: Ki= 225 nM (human); mAChR M4: Ki= 296 nM (human); CYP17A1: Ki= 325 nM (human); mAChR M3: Ki= 379 nM (human); DOR-1: Ki= 508 nM (human) |
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Names and Identifiers
| Pubchem Sid | 488179751 |
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| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179751 |
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| IUPAC Name | 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole |
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| INCHI | InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2 |
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| InChi Key | LEZWWPYKPKIXLL-UHFFFAOYSA-N |
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| Canonical SMILES | C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl |
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| Isomeric SMILES | C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl |
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| PubChem CID | 3198 |
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| Molecular Weight | 381.68 |
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| Beilstein | 964150 |
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Chemical and Physical Properties
| Refractive Index | n20D1.62 (Predicted) |
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| Boil Point(°C) | ~533.8° C at 760 mmHg (Predicted) |
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| Melt Point(°C) | 91-94° C |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H302:Harmful if swallowed |
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| Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
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| Merck Index | 3.01527777777778 |
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