| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| E408927-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $266.90 |
Rho Inhibitors
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information EHT 1864 2HCl EHT 1864 2HCl is a potent Rac family GTPase inhibitor with K d of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 selectively inhibits Rac-induced lamellipodia formation, and specifically reverses cell transformation induced by constitutively activated mutants of Rac1 and Tiam1. EHT 1864 strongly impaires oncogenic Ras-induced cell proliferation in NIH 3T3 cells stably expressing H-Ras(61L) protein. EHT 1864 also reduces both extracellular and intracellular levels of Aβ peptides by inhibiting the γ-secretase-dependent cleavage of APP. In cultured hippocampal pyramidal neurons, EHT 1864, via inhibition of Rac1, rescues the phenotype induced by Rich2 knock-down. In vivo EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains. cell lines： Concentrations：~5 μM Incubation Time：4 days Powder Purity:≥99% |
| Canonical SMILES | Cl.Cl.FC(F)(F)C1=CC2=C(C=C1)C(=CC=N2)SCCCCCOC3=COC(=CC3=O)CN4CCOCC4 |
|---|---|
| Molecular Weight | 581.47 |
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