eIF4A3-IN-12 (compound 62) is a silvestrol ( HY-13251 ) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC 50 s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis.