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Elacridar - ≥98%, high purity , CAS No.143664-11-3

≥98%

CAS#: 143664-11-3
Formula: C₃₄H₃₃N₃O₅
Molecular Weight: 563.64
MDL number: MFCD00912604
PubChem CID: 119373

Item Number

E126576

Grouped product items
SKU	Size	Availability	Price
E126576-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$11.90
E126576-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$44.90
E126576-10mg	10mg	In stock	$70.90
E126576-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$156.90
E126576-50mg	50mg	In stock	$248.90
E126576-100mg	100mg	In stock	$367.90
E126576-250mg	250mg	In stock	$828.90
E126576-1g	1g	In stock	$2,980.90

View related series

cancer research

Basic Description

Synonyms	Elacridar\|143664-11-3\|GF120918\|Elacridar [INN]\|GF-120918\|GG918\|N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide\|Elacridar (GF120918)\|GF 120918\|CHEMBL396298\|N-(4-(2-(6,7-dimethoxy-3,4-dihydrois
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	A prototypical BCRP (ABCG2) and MDR-1 inhibitor which inhibits the Bcrp1-mediated transport. It increases the availablity of cytotoxic antitumor drugs. Allows the uptake of more anti-HIV drugs in the brain and CNS.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. A prototypical BCRP (ABCG2) inhibitor.

Associated Targets

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB1 Tchem Multidrug resistance protein 1 5 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 0 Activities

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 0 Activities

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ABCG2 Tchem ATP-binding cassette sub-family G member 2 7 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC1 Tchem Multidrug resistance-associated protein 1 0 Activities

Discover Target: ABCC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
INCHI	InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
InChi Key	OSFCMRGOZNQUSW-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
Isomeric SMILES	COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
WGK Germany	3
RTECS	AR7621300
PubChem CID	119373
Molecular Weight	563.64

Certificates

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7 results found

Lot Number	Certificate Type	Date	Item
A1515015	Certificate of Analysis	Jun 12, 2024	E126576
F2217258	Certificate of Analysis	Apr 02, 2024	E126576
F2414031	Certificate of Analysis	Sep 19, 2023	E126576
L2109526	Certificate of Analysis	Sep 19, 2023	E126576
L2109527	Certificate of Analysis	Sep 19, 2023	E126576
L2109528	Certificate of Analysis	Sep 19, 2023	E126576
L2109530	Certificate of Analysis	Sep 19, 2023	E126576

Solubility

Soluble in chloroform, dichloromethane, DMSO, and methanol.

Sensitivity

Heat Sensitive

Melt Point(°C)

210 °C

WGK Germany

RTECS

AR7621300

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