eliapixant , CAS No.1948229-21-7, Antagonist of P2X3

Item Number

E610099

Grouped product items
SKU	Size	Availability	Price	Qty
E610099-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$240.90
E610099-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$830.90

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Basic Description

Synonyms	Eliapixant\|Eliapixant [INN]\|Eliapixant [USAN]\|1948229-21-7\|9GH7E6347B\|Eliapixant [USAN:INN]\|BAY1817080\|BAY 1817080\|BAY-1817080\|UNII-9GH7E6347B\|WHO 11269\|3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-oxolan-3-yl]oxy-N-[(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]eth
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2X3

Names and Identifiers

IUPAC Name	3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-oxolan-3-yl]oxy-N-[(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]benzamide
INCHI	InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1
InChi Key	GTQPEQGDLVSFJO-CXAGYDPISA-N
Canonical SMILES	Cc1cnc(s1)c1cc(cc(c1)O[C@@H]1CCOC1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Isomeric SMILES	CC1=CN=C(S1)C2=CC(=CC(=C2)O[C@@H]3CCOC3)C(=O)N[C@H](C)C4=CN=C(N=C4)C(F)(F)F
PubChem CID	121397587

PubChem CID

CAS Registry No.

BindingDB Ligand

References

1. Morice A, Smith JA, McGarvey L, Birring SS, Parker SM, Turner A, Hummel T, Gashaw I, Fels L, Klein S et al.. (2021) Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study.. Eur Respir J, 58 (5): (2004240). [PMID:33986030]
2. Davenport AJ, Neagoe I, Bräuer N, Koch M, Rotgeri A, Nagel J, Laux-Biehlmann A, Machet F, Coelho AM, Boyce S et al.. (2021) Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers.. Sci Rep, 11 (1): (19877). [PMID:34615939]

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Basic Description