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ELQ-300 - 98%, high purity , CAS No.1354745-52-0

Moligand™
≥98%

CAS#: 1354745-52-0
Formula: C₂₄H₁₇ClF₃NO₄
Molecular Weight: 475.85
PubChem CID: 67016608

Item Number

E412133

Grouped product items
SKU	Size	Availability	Price
E412133-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$118.90
E412133-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$189.90
E412133-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$379.90
E412133-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$607.90

View related series

Plasmodium falciparum cytochrome b

Basic Description

Synonyms	ELQ-300\|1354745-52-0\|ELQ300\|6-chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one\|BRC5YE92RX\|6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-quinolin-4-one\|6-Chloro-7-methoxy-2-methyl-3-{4-[4-(tri
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information ELQ-300, a bioavailable antimalarial agent, is a potent and orally inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1).

Names and Identifiers

IUPAC Name	6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-quinolin-4-one
INCHI	InChI=1S/C24H17ClF3NO4/c1-13-22(23(30)18-11-19(25)21(31-2)12-20(18)29-13)14-3-5-15(6-4-14)32-16-7-9-17(10-8-16)33-24(26,27)28/h3-12H,1-2H3,(H,29,30)
InChi Key	WZDNKHCQIZRDKW-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=O)C2=CC(=C(C=C2N1)OC)Cl)C3=CC=C(C=C3)OC4=CC=C(C=C4)OC(F)(F)F
Isomeric SMILES	CC1=C(C(=O)C2=CC(=C(C=C2N1)OC)Cl)C3=CC=C(C=C3)OC4=CC=C(C=C4)OC(F)(F)F
PubChem CID	67016608
Molecular Weight	475.85

PubChem CID

67016608

ChEMBL Ligand

CHEMBL2431810

CAS Registry No.

1354745-52-0

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
B2419078	Certificate of Analysis	Jan 06, 2024	E412133
B2419080	Certificate of Analysis	Jan 06, 2024	E412133
B2419083	Certificate of Analysis	Jan 06, 2024	E412133
B2419085	Certificate of Analysis	Jan 06, 2024	E412133
B2419088	Certificate of Analysis	Jan 06, 2024	E412133
B2419089	Certificate of Analysis	Jan 06, 2024	E412133
B2419092	Certificate of Analysis	Jan 06, 2024	E412133
B2419093	Certificate of Analysis	Jan 06, 2024	E412133

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

References

1. Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R. (2010) Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.. J Med Chem, 53 (19): (7076-94). [PMID:20828199]
2. Winter R, Kelly JX, Smilkstein MJ, Hinrichs D, Koop DR, Riscoe MK. (2011) Optimization of endochin-like quinolones for antimalarial activity.. Exp Parasitol, 127 (2): (545-51). [PMID:21040724]
3. Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE et al.. (2013) Quinolone-3-diarylethers: a new class of antimalarial drug.. Sci Transl Med, 5 (177): (177ra37). [PMID:23515079]
4. Stickles AM, de Almeida MJ, Morrisey JM, Sheridan KA, Forquer IP, Nilsen A, Winter RW, Burrows JN, Fidock DA, Vaidya AB et al.. (2015) Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.. Antimicrob Agents Chemother, 59 (4): (1977-82). [PMID:25605352]
5. Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM et al.. (2015) ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.. Antimicrob Agents Chemother, 59 (9): (5555-60). [PMID:26124159]
6. Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH et al.. (2017) Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.. ACS Infect Dis, 3 (10): (728-735). [PMID:28927276]

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