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Applications
Targets
G protein-coupled receptors (GPCRs)
5-Hydroxytryptamine receptors
EMD 386088 hydrochloride - ≥99%(HPLC), high purity , CAS No.1171123-46-8, Agonist of 5-HT 6 receptor

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EMD 386088 hydrochloride - ≥99%(HPLC), high purity , CAS No.1171123-46-8, Agonist of 5-HT 6 receptor

Moligand™
≥99%(HPLC)

CAS#: 1171123-46-8
Formula: C₁₄H₁₅N₂Cl•HCl
Molecular Weight: 283.20
PubChem CID: 56972198

Item Number

E288344

Grouped product items
SKU	Size	Availability	Price
E288344-5mg	5mg	In stock	$103.90
E288344-10mg	10mg	In stock	$118.90
E288344-25mg	25mg	In stock	$356.90
E288344-50mg	50mg	In stock	$479.90
E288344-100mg	100mg	In stock	$1,135.90

Potent 5-HT6agonist

View related series

5-HT6 receptor Agonist

Basic Description

Synonyms	EMD 386088 HYDROCHLORIDE\|1171123-46-8\|EMD386088\|EMD386088Hydrochloride\|5-Chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole hydrochloride\|5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-Indole hydrochloride\|EMD 386088\|EMD386088 hydrochlo
Specifications & Purity	≥99%(HPLC)
Storage Temp	Room temperature,Desiccated
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of 5-HT 6 receptor
Product Description	EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induced cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential to study Alzheimer's disease (AD) and schizophrenia

Associated Targets

HTR6 Tchem 5-hydroxytryptamine receptor 6 1 Activities

Discover Target: HTR6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole;hydrochloride
INCHI	InChI=1S/C14H15ClN2.ClH/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9;/h2-4,8,16-17H,5-7H2,1H3;1H
InChi Key	WWSNDUWIZDYGIQ-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl
Isomeric SMILES	CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl
WGK Germany	3
PubChem CID	56972198
Molecular Weight	283.20

Database links

CAS Registry No.	1171123-46-8
PubChem CID	10131112
ChEMBL Ligand	CHEMBL364005
GPCRdb Ligand	EMD-386088

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
A2420186	Certificate of Analysis	Dec 22, 2023	E288344
A2420187	Certificate of Analysis	Dec 22, 2023	E288344
A2420188	Certificate of Analysis	Dec 22, 2023	E288344
A2420189	Certificate of Analysis	Dec 22, 2023	E288344
A2420190	Certificate of Analysis	Dec 22, 2023	E288344
A2420191	Certificate of Analysis	Dec 22, 2023	E288344
A2420192	Certificate of Analysis	Dec 22, 2023	E288344
A2420193	Certificate of Analysis	Dec 22, 2023	E288344
A2420194	Certificate of Analysis	Dec 22, 2023	E288344
A2420195	Certificate of Analysis	Dec 22, 2023	E288344

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 7.08, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 28.32, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RIDADR	UN28116.1/PGIII

References

1. Mattsson C, Sonesson C, Sandahl A, Greiner HE, Gassen M, Plaschke J, Leibrock J, Böttcher H. (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.. Bioorg Med Chem Lett, 15 (19): (4230-4). [PMID:16055331]

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