Enerisant - 98%, high purity , CAS No.1152747-82-4, Antagonist of H 3 receptor

Item Number

E610131

Grouped product items
SKU	Size	Availability	Price	Qty
E610131-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
E610131-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	Enerisant\|Enerisant [INN]\|UNII-E2Y97PQY3A\|E2Y97PQY3A\|1152747-82-4\|Methanone, (1-(4-(3-((2R)-2-methyl-1-pyrrolidinyl)propoxy)phenyl)-1H-pyrazol-4-yl)-4-morpholinyl-\|SCHEMBL1179419\|GTPL11293\|IABXVJILZYNSTM-GOSISDBHSA-N\|HY-17610\|CS-0014688\|Q27276798\|[1-[4-[3
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of H 3 receptor
Product Description	Enerisant (TS-091) is a potent, highly selective, competitive active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively.

Names and Identifiers

IUPAC Name	[1-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyrazol-4-yl]-morpholin-4-ylmethanone
INCHI	InChI=1S/C22H30N4O3/c1-18-4-2-9-24(18)10-3-13-29-21-7-5-20(6-8-21)26-17-19(16-23-26)22(27)25-11-14-28-15-12-25/h5-8,16-18H,2-4,9-15H2,1H3/t18-/m1/s1
InChi Key	IABXVJILZYNSTM-GOSISDBHSA-N
Canonical SMILES	C[C@@H]1CCCN1CCCOc1ccc(cc1)n1ncc(c1)C(=O)N1CCOCC1
Isomeric SMILES	C[C@@H]1CCCN1CCCOC2=CC=C(C=C2)N3C=C(C=N3)C(=O)N4CCOCC4
PubChem CID	42601503
Molecular Weight	398.50

PubChem CID

CAS Registry No.

GPCRdb Ligand

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4 results found

Lot Number	Certificate Type	Date	Item
G2410108	Certificate of Analysis	May 27, 2024	E610131
G2410109	Certificate of Analysis	May 27, 2024	E610131
G2410348	Certificate of Analysis	May 27, 2024	E610131
G2410349	Certificate of Analysis	May 27, 2024	E610131

References

1. Hino N, Marumo T, Kotani M, Shimazaki T, Kaku-Fukumoto A, Hikichi H, Karasawa JI, Tomishima Y, Komiyama H, Tatsuda E et al.. (2020) A Novel Potent and Selective Histamine H₃ Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, and Wake-Promoting and Procognitive Effects in Rodents.. J Pharmacol Exp Ther, 375 (2): (276-285). [PMID:32862143]

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Basic Description