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(-)-englerin A , CAS No.E610133, Activator of TRPC4;Activator of TRPC5

  • Moligand™
Item Number
E610133
Grouped product items
SKUSizeAvailabilityPrice Qty
E610133-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
E610133-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,540.90
View related series
TRPC4 Activator TRPC5 Activator

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of TRPC4;Activator of TRPC5

Associated Targets

TRPC4 Tchem Short transient receptor potential channel 4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCD Tclin Protein kinase C delta type 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

INCHI InChI=1S/C26H34O6/c1-16(2)26-14-20(30-22(29)15-27)25(4,32-26)19-12-10-17(3)23(19)24(26)31-21(28)13-11-18-8-6-5-7-9-18/h5-9,11,13,16-17,19-20,23-24,27H,10,12,14-15H2,1-4H3/b13-11+/t17-,19-,20-,23-,24+,25+,26-/m1/s1
InChi Key GACOFEKSDCOVMV-RRYXBOBMSA-N
Canonical SMILES OCC(=O)O[C@@H]1C[C@@]2(O[C@@]1(C)[C@@H]1CC[C@H]([C@H]1[C@@H]2OC(=O)/C=C/c1ccccc1)C)C(C)C
Isomeric SMILES C[C@@H]1CC[C@@H]2[C@@H]1[C@@H]([C@@]3(C[C@H]([C@]2(O3)C)OC(=O)CO)C(C)C)OC(=O)/C=C/C4=CC=CC=C4
PubChem CID 46242512

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.  (2009)  Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri..  Org Lett,  11  (1): (57-60).  [PMID:19061394]
2. Zhou Q, Chen X, Ma D.  (2010)  Asymmetric, protecting-group-free total synthesis of (-)-englerin A..  Angew Chem Int Ed Engl,  49  (20): (3513-6).  [PMID:20544902]
3. Molawi K, Delpont N, Echavarren AM.  (2010)  Enantioselective synthesis of (-)-englerins A and B..  Angew Chem Int Ed Engl,  49  (20): (3517-9).  [PMID:20544903]
4. Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C, Fröhlich R, Habenberger P, Waldmann H, Christmann M.  (2011)  Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile..  Angew Chem Int Ed Engl,  50  (17): (3998-4002).  [PMID:21472928]
5. Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S et al..  (2015)  (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels..  Angew Chem Int Ed Engl,  54  (12): (3787-91).  [PMID:25707820]

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