(-)-englerin A , CAS No.E610133, Activator of TRPC4;Activator of TRPC5

Item Number
E610133
Grouped product items
SKUSizeAvailabilityPrice Qty
E610133-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
E610133-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,540.90
View related series
TRPC4 Activator TRPC5 Activator

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of TRPC4;Activator of TRPC5

Associated Targets(Human)

TRPC4 Tchem Short transient receptor potential channel 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPC5 Tchem Short transient receptor potential channel 5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXF 393 (41971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK-10 (45540 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UO-31 (46270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRPC5 Tchem Short transient receptor potential channel 5 (300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKD3 Tchem Protein kinase C (PKC) (1010 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

INCHI InChI=1S/C26H34O6/c1-16(2)26-14-20(30-22(29)15-27)25(4,32-26)19-12-10-17(3)23(19)24(26)31-21(28)13-11-18-8-6-5-7-9-18/h5-9,11,13,16-17,19-20,23-24,27H,10,12,14-15H2,1-4H3/b13-11+/t17-,19-,20-,23-,24+,25+,26-/m1/s1
InChi Key GACOFEKSDCOVMV-RRYXBOBMSA-N
Canonical SMILES OCC(=O)O[C@@H]1C[C@@]2(O[C@@]1(C)[C@@H]1CC[C@H]([C@H]1[C@@H]2OC(=O)/C=C/c1ccccc1)C)C(C)C
Isomeric SMILES C[C@@H]1CC[C@@H]2[C@@H]1[C@@H]([C@@]3(C[C@H]([C@]2(O3)C)OC(=O)CO)C(C)C)OC(=O)/C=C/C4=CC=CC=C4
PubChem CID 46242512

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.  (2009)  Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri..  Org Lett,  11  (1): (57-60).  [PMID:19061394] [10.1021/op500134e]
2. Zhou Q, Chen X, Ma D.  (2010)  Asymmetric, protecting-group-free total synthesis of (-)-englerin A..  Angew Chem Int Ed Engl,  49  (20): (3513-6).  [PMID:20544902] [10.1021/op500134e]
3. Molawi K, Delpont N, Echavarren AM.  (2010)  Enantioselective synthesis of (-)-englerins A and B..  Angew Chem Int Ed Engl,  49  (20): (3517-9).  [PMID:20544903] [10.1021/op500134e]
4. Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C, Fröhlich R, Habenberger P, Waldmann H, Christmann M.  (2011)  Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile..  Angew Chem Int Ed Engl,  50  (17): (3998-4002).  [PMID:21472928] [10.1021/op500134e]
5. Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S et al..  (2015)  (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels..  Angew Chem Int Ed Engl,  54  (12): (3787-91).  [PMID:25707820] [10.1021/op500134e]

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