Epcoritamab (anti-CD3&CD20) - Primary antibody, specific to CD3E & MS4A1, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e

Features and benefits

Short Overview:
Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Cynomolgus monkey,Human
Isotype: Human IgG1

Application:

Item Number

Ab175531

Grouped product items
SKU	Size	Availability	Price
Ab175531-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$179.90
Ab175531-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$899.90
Ab175531-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,249.90
Ab175531-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,599.90

Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

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Basic Description

Product Name	Epcoritamab (anti-CD3&CD20) - Primary antibody, specific to CD3E & MS4A1, Human IgG1
Synonyms	GEN-3013;GEN3013
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥90%(SDS-PAGE&SEC), Lot by Lot
Specificity	CD3E & MS4A1
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	BINDING AGENT
Mechanism of action	Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e
Product Description	Epcoritamab (anti-CD3 & CD20) is an bispecific IgG1 antibody redirecting T-cells toward CD3×CD20+ tumor cells. Epcoritamab (anti-CD3 & CD20) induces potent T-cell-mediated cytotoxicity towards B-cell NHL cell lines. Purity ≥90% (SDS-PAGE&SEC) Endotoxin Level ≤1.0EU/mg

Product Properties

Isotype	Human IgG1
Light Chain Type	lambda
SDS-PAGE	146.28 kDa
Purification Method	Protein A purified
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	2134641-34-0

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. van der Horst HJ, de Jonge AV, Hiemstra IH, Gelderloos AT, Berry DRAI, Hijmering NJ, van Essen HF, de Jong D, Chamuleau MED, Zweegman S et al.. (2021) Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment.. Blood Cancer J, 11 (2): (38). [PMID:33602901]
2. Engelberts PJ, Hiemstra IH, de Jong B, Schuurhuis DH, Meesters J, Beltran Hernandez I, Oostindie SC, Neijssen J, van den Brink EN, Horbach GJ et al.. (2020) DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.. EBioMedicine, 52 (3): (102625). [PMID:31981978]

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Basic Description