Epertinib hydrochloride - 99%, high purity , CAS No.2071195-74-7

Item Number

E413670

Grouped product items
SKU	Size	Availability	Price
E413670-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$78.90
E413670-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$236.90
E413670-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$377.90
E413670-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$658.90
E413670-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$921.90

HER2/ErbB2 Selective Inhibitors

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Basic Description

Synonyms	Epertinib HCl；S-222611 hydrochloride；S-222611 HCl
Specifications & Purity	99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information Epertinib hydrochloride (S-222611 hydrochloride) is a potent, orally active, reversible, and selectivetyrosine kinaseinhibitor ofEGFR,HER2andHER4with IC50 of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity. Targets EGFR (Cell-free assay); HER4 (Cell-free assay); HER2 (Cell-free assay) 1.48 nM; 2.49 nM; 7.15 nM

Names and Identifiers

IUPAC Name	N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[(Z)-N-[[(3R)-morpholin-3-yl]methoxy]-C-prop-1-ynylcarbonimidoyl]quinazolin-4-amine;hydrochloride
INCHI	InChI=1S/C30H27ClFN5O3.ClH/c1-2-4-27(37-40-18-24-17-38-12-11-33-24)21-7-9-28-25(14-21)30(35-19-34-28)36-23-8-10-29(26(31)15-23)39-16-20-5-3-6-22(32)13-20;/h3,5-10,13-15,19,24,33H,11-12,16-18H2,1H3,(H,34,35,36);1H/b37-27+;/t24-;/m1./s1
InChi Key	NVWJPQQXBPWOOA-PLXRJBJVSA-N
Canonical SMILES	CC#CC(=NOCC1COCCN1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl
PubChem CID	139290994
Molecular Weight	596.48

Solubility

Solubility (25°C) In vitro DMSO: 100 mg/mL (167.65 mM); Water: Insoluble; Ethanol: Insoluble;

Sensitivity

Moisture sensitive

Solution Calculators

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Basic Description