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EPZ005687 - ≥98%, high purity , CAS No.1396772-26-1, Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

  • Moligand™
  • ≥98%
Item Number
E125682
Grouped product items
SKUSizeAvailabilityPrice Qty
E125682-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$64.90
E125682-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$97.90
E125682-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$271.90
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enhancer of zeste 2 polycomb repressive complex 2 subunit Inhibitor

Basic Description

SynonymsEPZ005687|1396772-26-1|EPZ-005687|1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide|EPZ 005687|1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmet
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit
Product Description

EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases

Associated Targets

EZH1 Tchem Histone-lysine N-methyltransferase EZH1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 9 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl)phenyl]indazole-4-carboxamide
INCHI InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
InChi Key ZOIBZSZLMJDVDQ-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C
Isomeric SMILES CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C
PubChem CID 60160561
Molecular Weight 539.67

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1 results found

Lot NumberCertificate TypeDateItem
G1502199Certificate of AnalysisJan 09, 2023 E125682

Chemical and Physical Properties

SolubilityDMSO

Related Documents

 SDS

 Specification Sheet

References

1. Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, Sacks JD, Raimondi A, Majer CR, Song J et al..  (2012)  A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells..  Nat Chem Biol,  8  (11): (890-6).  [PMID:23023262]

Solution Calculators

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