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EPZ015666 - 98% (HPLC), high purity , CAS No.1616391-65-1, Inhibitor of protein arginine methyltransferase 5

≥98%(HPLC)

CAS#: 1616391-65-1
Formula: C₂₀H₂₅N₅O₃
Molecular Weight: 383.44
PubChem CID: 90241673

Item Number

E167694

Grouped product items
SKU	Size	Availability	Price
E167694-5mg	5mg	In stock	$107.90
E167694-25mg	25mg	In stock	$486.90
E167694-50mg	50mg	In stock	$489.90
E167694-100mg	100mg	In stock	$706.90

Selective, potent PRMT5 inhibitor

View related series

protein arginine methyltransferase 5 Inhibitor

Basic Description

Synonyms	(S)-N-(3-(3，4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide，GSK3235025，YQ36286
Specifications & Purity	98% (HPLC)
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein arginine methyltransferase 5

Names and Identifiers

IUPAC Name	N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
INCHI	InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1
InChi Key	ZKXZLIFRWWKZRY-KRWDZBQOSA-N
Canonical SMILES	C1CN(CC2=CC=CC=C21)CC(CNC(=O)C3=CC(=NC=N3)NC4COC4)O
Isomeric SMILES	C1CN(CC2=CC=CC=C21)C[C@H](CNC(=O)C3=CC(=NC=N3)NC4COC4)O
PubChem CID	90241673
Molecular Weight	383.44

PubChem CID

90241673

CAS Registry No.

1616391-65-1

RCSB PDB Ligand

3XV

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4 results found

Lot Number	Certificate Type	Date	Item
J2226404	Certificate of Analysis	Aug 22, 2022	E167694
J2226410	Certificate of Analysis	Aug 22, 2022	E167694
J2226419	Certificate of Analysis	Aug 22, 2022	E167694
J2226526	Certificate of Analysis	Aug 22, 2022	E167694

References

1. Branscombe TL, Frankel A, Lee JH, Cook JR, Yang Z, Pestka S, Clarke S. (2001) PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.. J Biol Chem, 276 (35): (32971-6). [PMID:11413150]
2. Pal S, Baiocchi RA, Byrd JC, Grever MR, Jacob ST, Sif S. (2007) Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.. EMBO J, 26 (15): (3558-69). [PMID:17627275]
3. Copeland RA. (2013) Molecular pathways: protein methyltransferases in cancer.. Clin Cancer Res, 19 (23): (6344-50). [PMID:23958745]
4. Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers LW, Agostinelli C, Pileri S, Denis GV, Baiocchi RA et al.. (2013) Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.. J Biol Chem, 288 (49): (35534-47). [PMID:24189068]
5. Park JH, Szemes M, Vieira GC, Melegh Z, Malik S, Heesom KJ, Von Wallwitz-Freitas L, Greenhough A, Brown KW, Zheng YG et al.. (2015) Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells.. Mol Oncol, 9 (3): (617-27). [PMID:25475372]
6. Li Y, Chitnis N, Nakagawa H, Kita Y, Natsugoe S, Yang Y, Li Z, Wasik M, Klein-Szanto AJ, Rustgi AK et al.. (2015) PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers.. Cancer Discov, 5 (3): (288-303). [PMID:25582697]
7. Stopa N, Krebs JE, Shechter D. (2015) The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.. Cell Mol Life Sci, 72 (11): (2041-59). [PMID:25662273]
8. Yang F, Wang J, Ren HY, Jin J, Wang AL, Sun LL, Diao KX, Wang EH, Mi XY. (2015) Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression.. Tumour Biol, 36 (8): (5901-11). [PMID:25704480]
9. Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT et al.. (2015) Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.. Blood, 125 (16): (2530-43). [PMID:25742700]

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EPZ015666 - 98% (HPLC), high purity , CAS No.1616391-65-1, Inhibitor of protein arginine methyltransferase 5

Basic Description

Associated Targets

PRMT5 Tchem Protein arginine N-methyltransferase 5 3 Activities