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Eribaxaban - 98%, high purity , CAS No.536748-46-6, Inhibitor of coagulation factor X

Moligand™
≥98%

CAS#: 536748-46-6
Formula: C₂₄H₂₂ClFN₄O₄
Molecular Weight: 484.91
PubChem CID: 11634458

Item Number

E610176

Grouped product items
SKU	Size	Availability	Price	Qty
E610176-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$270.90
E610176-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$940.90

View related series

coagulation factor X Inhibitor

Basic Description

Synonyms	eribaxaban\|536748-46-6\|PD-0348292\|PD0348292\|Eribaxaban (USAN)\|Eribaxaban [USAN]\|PD 348292\|PD 0348292\|PD 348,292\|5FCH6YDY7Z\|PD-348292\|CHEMBL476186\|(2R,4R)-1-N-(4-chlorophenyl)-2-N-[2-fluoro-4-(2-oxopyridin-1-yl)phenyl]-4-methoxypyrrolidine-1,2-dicarboxamid
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of coagulation factor X
Product Description	Eribaxaban (PD348292, PD0348292) is an oral factor Xa inhibitor, it is expected to develop for the treatment and prevention of thrombotic disease.

Names and Identifiers

IUPAC Name	(2R,4R)-N-(4-chlorophenyl)-N'-[2-fluoro-4-(2-oxopyridin-1-yl)phenyl]-4-methoxypyrrolidine-1,2-dicarboxamide
INCHI	InChI=1S/C24H22ClFN4O4/c1-34-18-13-21(30(14-18)24(33)27-16-7-5-15(25)6-8-16)23(32)28-20-10-9-17(12-19(20)26)29-11-3-2-4-22(29)31/h2-12,18,21H,13-14H2,1H3,(H,27,33)(H,28,32)/t18-,21-/m1/s1
InChi Key	QQBKAVAGLMGMHI-WIYYLYMNSA-N
Canonical SMILES	CO[C@@H]1C[C@@H](N(C1)C(=O)Nc1ccc(cc1)Cl)C(=O)Nc1ccc(cc1F)n1ccccc1=O
Isomeric SMILES	CO[C@@H]1C[C@@H](N(C1)C(=O)NC2=CC=C(C=C2)Cl)C(=O)NC3=C(C=C(C=C3)N4C=CC=CC4=O)F
PubChem CID	11634458
Molecular Weight	484.91

ChEMBL Ligand

CAS Registry No.

DrugBank Ligand

PubChem CID

RCSB PDB Ligand

Reactome Reaction

R-HSA-9015122, R-HSA-9015111

Reactome Drug

R-ALL-9603671

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
G2418228	Certificate of Analysis	Apr 16, 2024	E610176
G2418274	Certificate of Analysis	Apr 16, 2024	E610176
G2418283	Certificate of Analysis	Apr 16, 2024	E610176
G2418287	Certificate of Analysis	Apr 16, 2024	E610176

References

1. Eriksson BI, Quinlan DJ, Weitz JI. (2009) Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.. Clin Pharmacokinet, 48 (1): (1-22). [PMID:19071881]
2. Bondarenko M, Curti C, Montana M, Rathelot P, Vanelle P. (2013) Efficacy and toxicity of factor Xa inhibitors.. J Pharm Pharm Sci, 16 (1): (74-88). [PMID:23683607]
3. Cohen AT, Boyd RA, Mandema JW, Dicarlo L, Pak R, A5571010 Investigators. (2013) An adaptive-design dose-ranging study of PD 0348292, an oral factor Xa inhibitor, for thromboprophylaxis after total knee replacement surgery.. J Thromb Haemost, 11 (8): (1503-10). [PMID:23782955]

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Eribaxaban - 98%, high purity , CAS No.536748-46-6, Inhibitor of coagulation factor X

Basic Description

Associated Targets

F10 Tclin Coagulation factor X 3 Activities