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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E646973-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $480.90 | |
E646973-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $800.90 | |
E646973-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,800.90 | |
E646973-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $4,300.90 |
Synonyms | Etamicastat HCl|Etamicastat (hydrochloride)|ETAMICASTAT HYDROCHLORIDE|677773-32-9|677773-32-9 (HCl)|(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride|(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dih |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase ( DBH ) inhibitor with an IC 50 value of 107 nM. Etamicastat can be used in the research of cardiovascular diseases. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Product Description | Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase ( DBH ) inhibitor with an IC 50 value of 107 nM Etamicastat can be used in the research of cardiovascular diseases . In Vitro Etamicastat blocks the hERG current amplitude with an IC 50 value of 44 μg/mL (141 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels . Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), C max (4.9 nM), and terminal elimination half-lives (T 1/2 =3.7 h) in male Wistar rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NMRi mice Dosage: 100 mg/kg Administration: Administered intraperitoneally Result: Led to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control). Animal Model: Male Wistar rats Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: Orally administered with at a dose volume of 10 mL/kg Result: Oral bioavailability (64%), C max (4.9 nM), and (T 1/2 =3.7 h). Form:Solid IC50& Target:IC50: 107 nM (DBH) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 4-(2-aminoethyl)-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione;hydrochloride |
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INCHI | InChI=1S/C14H15F2N3OS.ClH/c15-9-3-8-4-11(7-20-13(8)12(16)5-9)19-10(1-2-17)6-18-14(19)21;/h3,5-6,11H,1-2,4,7,17H2,(H,18,21);1H/t11-;/m1./s1 |
InChi Key | CKRDOSZCFINPAD-RFVHGSKJSA-N |
Canonical SMILES | C1C(COC2=C1C=C(C=C2F)F)N3C(=CNC3=S)CCN.Cl |
Isomeric SMILES | C1[C@H](COC2=C1C=C(C=C2F)F)N3C(=CNC3=S)CCN.Cl |
Alternate CAS | 677773-32-9 |
PubChem CID | 10450386 |
Molecular Weight | 347.81 |
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Solubility | DMSO : 100 mg/mL (287.51 mM; Need ultrasonic) H2O : 16.67 mg/mL (47.93 mM; Need ultrasonic) |
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