exarafenib - ≥98%, high purity , CAS No.2639957-39-2, Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase

Item Number

E610261

Grouped product items
SKU	Size	Availability	Price
E610261-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$238.90
E610261-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$319.90
E610261-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$563.90
E610261-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$839.90
E610261-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,160.90

View related series

Basic Description

Synonyms	Exarafenib\|Exarafenib [INN]\|KIN-2787 free base\|2VPX8HL8AB\|2639957-39-2\|UNII-2VPX8HL8AB\|(3S)-N-(3-(2-(((2R)-1-Hydroxypropan-2-yl)amino)-6- (morpholin-4-yl)pyridin-4-yl)-4-methylphenyl)-3-(2,2,2- trifluoroethyl)pyrrolidine-1-carboxamide\|1-Pyrrolidinecarboxa
Specifications & Purity	≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase
Product Description	Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity.

Names and Identifiers

IUPAC Name	(3S)-N-[3-[2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
INCHI	InChI=1S/C26H34F3N5O3/c1-17-3-4-21(31-25(36)34-6-5-19(15-34)14-26(27,28)29)13-22(17)20-11-23(30-18(2)16-35)32-24(12-20)33-7-9-37-10-8-33/h3-4,11-13,18-19,35H,5-10,14-16H2,1-2H3,(H,30,32)(H,31,36)/t18-,19+/m1/s1
InChi Key	GZMYLSJUNSCMTD-MOPGFXCFSA-N
Canonical SMILES	Cc1c(cc(cc1)NC(=O)N1CC[C@H](C1)CC(F)(F)F)c1cc(nc(c1)N1CCOCC1)N[C@H](C)CO
Isomeric SMILES	CC1=C(C=C(C=C1)NC(=O)N2CC[C@H](C2)CC(F)(F)F)C3=CC(=NC(=C3)N4CCOCC4)N[C@H](C)CO
PubChem CID	156297592
Molecular Weight	521.58

CAS Registry No.

PubChem CID

Solubility

DMSO: 50 mg/mL (95.86 mM), Sonication is recommended.

Sensitivity

Light sensitive;Moisture sensitive

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description