Basic Description

Synonyms	EXEMESTANE\|107868-30-4\|Aromasin\|6-Methyleneandrosta-1,4-diene-3,17-dione\|Aromasine\|Exemestano\|Exemestanum\|Fce 24304\|FCE-24304\|Exemestanum [INN-Latin]\|6-Methylene-androsta-1,4-diene-3,17-dione\|Exemestano [INN-Spanish]\|Androsta-1,4-diene-3,17-dione, 6-methy
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Irreversible steroidal aromatase inhibitor (IC50= 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Cytochrome P450 19A1 inhibitor

Product Properties

ALogP	3.1

IUPAC Name	(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
INCHI	InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
InChi Key	BFYIZQONLCFLEV-DAELLWKTSA-N
Canonical SMILES	CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C
Isomeric SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC(=C)C4=CC(=O)C=C[C@]34C
WGK Germany	3
PubChem CID	60198
Molecular Weight	296.403

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
G2227788	Certificate of Analysis	May 20, 2024	E129476
G2227789	Certificate of Analysis	May 20, 2024	E129476
G2227790	Certificate of Analysis	May 20, 2024	E129476

Solubility	Solvent:DMSO, Max Conc. mg/mL: 29.64, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 22.23, Max Conc. mM: 75

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H411:Toxic to aquatic life with long lasting effects H360:May damage fertility or the unborn child
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3

1. Pagani O, Regan MM, Walley BA, Fleming GF, Colleoni M, Láng I, Gomez HL, Tondini C, Burstein HJ, Perez EA et al.. (2014) Adjuvant exemestane with ovarian suppression in premenopausal breast cancer.. N Engl J Med, 371 (2): (107-18). [PMID:24881463]

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

SKU	Size	Availability	Price
E129476-250mg	250mg	In stock	$344.90
E129476-1g	1g	In stock	$1,092.90
E129476-5g	5g	In stock	$3,434.90