Calcium Fluorescent Probe Fluo-8, AM , CAS No.1345980-40-6

Item Number
F141112
Grouped product items
SKUSizeAvailabilityPrice Qty
F141112-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$984.90

Medium affinity green fluorescent calcium binding dye. Cell-permeable.

Basic Description

SynonymsHY-W127707 | CS-0185905 | Fluo-8 AM | 1345980-40-6 | acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-4-[3-(acetyloxymethoxy)-6-oxoxanthen-9-yl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate | SCHEMBL828166
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Names and Identifiers

IUPAC Name acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-4-[3-(acetyloxymethoxy)-6-oxoxanthen-9-yl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
INCHI InChI=1S/C50H50N2O23/c1-30(53)65-25-70-37-12-14-39-44(20-37)75-43-19-36(58)11-13-38(43)50(39)35-10-15-41(52(23-48(61)73-28-68-33(4)56)24-49(62)74-29-69-34(5)57)45(18-35)64-17-16-63-42-9-7-6-8-40(42)51(21-46(59)71-26-66-31(2)54)22-47(60)72-27-67-32(3)55/h6-15,18-20H,16-17,21-29H2,1-5H3
InChi Key BKYHTWFRZPRHNM-UHFFFAOYSA-N
Canonical SMILES CC(=O)OCOC1=CC2=C(C=C1)C(=C3C=CC(=O)C=C3O2)C4=CC(=C(C=C4)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC5=CC=CC=C5N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
Isomeric SMILES CC(=O)OCOC1=CC2=C(C=C1)C(=C3C=CC(=O)C=C3O2)C4=CC(=C(C=C4)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC5=CC=CC=C5N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
PubChem CID 54575324
Molecular Weight C51H52N2O23

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P264:Wash hands [and …] thoroughly after handling.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

Related Documents

References

1. Tyurin-Kuzmin PA et al..  (2016)  Activation of ß-adrenergic receptors is required for elevated a1A-adrenoreceptors expression and signaling in mesenchymal stromal cells..  Sci Rep,  (32835).  [PMID:27596381]
2. Luo Q et al..  (2021)  Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage..  Theranostics,  11  (12): (5986-6005).  [PMID:33897894]
3. Wang J et al..  (2021)  Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis..  ACS Nano,  15  (9): (14360-14372).  [PMID:34506129]
4. Leung G et al..  (2021)  ARPC1B binds WASP to control actin polymerization and curtail tonic signaling in B cells..  JCI Insight,  (23):   [PMID:34673575]
5. Taverner WK et al..  (2019)  Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCa Activation..  Mol Ther Oncolytics,  15  (117-130).  [PMID:31890865]
6. Dries E et al..  (2021)  CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices..  J Gen Physiol,  153  (6):   [PMID:33956073]
7. Ageeva LV et al..  (2018)  Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro..  Data Brief,  16  (327-333).  [PMID:29234689]
8. Kulebyakin K et al..  (2022)  Dynamic Balance between PTH1R-Dependent Signal Cascades Determines Its Pro- or Anti-Osteogenic Effects on MSC..  Cells,  11  (21):   [PMID:36359914]
9. Domínguez A et al..  (2019)  Effect of perfluorodecanoic acid on pig oocyte viability, intracellular calcium levels and gap junction intercellular communication during oocyte maturation in vitro..  Toxicol In Vitro,  58  (224-229).  [PMID:30946969]
10. Kielbik A et al..  (2021)  Effects of high-frequency nanosecond pulses on prostate cancer cells..  Sci Rep,  11  (15835).  [PMID:34349171]
11. Zummo FP et al..  (2021)  Exendin-4 stimulates autophagy in pancreatic ß-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis..  Autophagy,    (1-17).  [PMID:34338148]
12. Chen Z et al..  (2021)  Exercise mimetics and JAK inhibition attenuate IFN-?-induced wasting in engineered human skeletal muscle..  Sci Adv,  (4):   [PMID:33523949]
13. Cui W et al..  (2013)  Free fatty acid induces endoplasmic reticulum stress and apoptosis of ß-cells by Ca2+/calpain-2 pathways..  PLoS One,  (3): (e59921).  [PMID:23527285]
14. Guo Y et al..  (2021)  High doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts..  Mol Biol Rep,  48  (12): (7841-7851).  [PMID:34698990]
15. Datta G et al..  (2019)  HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells..  Front Cell Neurosci,  13  (329).  [PMID:31379513]
16. Dong L et al..  (2022)  Identification of a Partial and Selective TRPV1 Agonist CPIPC for Alleviation of Inflammatory Pain..  Molecules,  27  (17):   [PMID:36080196]
17. Eaton-Fitch N et al..  (2022)  Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients..  J Transl Med,  20  (94).  [PMID:35172836]
18. Sui S et al..  (2021)  iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma..  Invest Ophthalmol Vis Sci,  62  (10): (28).  [PMID:34427623]
19. Sysoeva VY et al..  (2017)  Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor..  Stem Cell Res,  25  (115-122).  [PMID:29127873]
20. Xian P et al..  (2019)  Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice..  Theranostics,  (20): (5956-5975).  [PMID:31534531]
21. Zhong X et al..  (2019)  Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells..  Cell Metab,  29  (4): (979-992.e4).  [PMID:30527743]
22. Ramachandran RP et al..  (2020)  Mitochondrial Targeting of the Enteropathogenic Escherichia coli Map Triggers Calcium Mobilization, ADAM10-MAP Kinase Signaling, and Host Cell Apoptosis..  mBio,  11  (5):   [PMID:32934081]
23. Li YC et al..  (2022)  Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1β-Induced Endothelium Injury..  Antioxidants (Basel),  11  (8):   [PMID:35892657]
24. Tyurin-Kuzmin PA et al..  (2018)  Noradrenaline Sensitivity Is Severely Impaired in Immortalized Adipose-Derived Mesenchymal Stem Cell Line..  Int J Mol Sci,  19  (12):   [PMID:30469522]
25. Oh JH et al..  (2018)  Phycoerythrin Peptide from Pyropia yezoensis Alleviates Endoplasmic Reticulum Stress Caused by Perfluorooctane Sulfonate-Induced Calcium Dysregulation..  Mar Drugs,  16  (2):   [PMID:29373516]
26. Zhang M et al..  (2018)  Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR..  J Bone Miner Res,      [PMID:30496623]
27. Lacroix JJ et al..  (2018)  Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1..  Nat Commun,  (2029).  [PMID:29795280]
28. Li C et al..  (2022)  Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers..  Biomed Res Int,  2022  (2777882).  [PMID:35028313]
29. Miao W et al..  (2016)  Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCß2..  Int J Mol Sci,  17  (10):   [PMID:27735862]
30. Li Y et al..  (2021)  Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis..  Redox Biol,  38  (101771).  [PMID:33189984]
31. Bender BJ et al..  (2019)  Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor..  Structure,  27  (3): (537-544.e4).  [PMID:30686667]
32. Xu W et al..  (2021)  Tet1 Regulates Astrocyte Development and Cognition of Mice Through Modulating GluA1..  Front Cell Dev Biol,  (644375).  [PMID:34778243]
33. Giraud-Gatineau A et al..  (2020)  The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection..  Elife,    [PMID:32369020]
34. Canales Coutiño B & Mayor R.  (2021)  The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration..  Development,  148  (23):   [PMID:34822717]
35. Mirali S et al..  (2020)  The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability..  Sci Transl Med,  12  (538):   [PMID:32269163]
36. Czeisler CM et al..  (2019)  The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis..  J Physiol,  597  (8): (2225-2251).  [PMID:30707772]
37. Zhu W et al..  (2021)  The role of Piezo1 in conventional aqueous humor outflow dynamics..  iScience,  24  (2): (102042).  [PMID:33532718]
38. Cane MC et al..  (2016)  The two pore channel TPC2 is dispensable in pancreatic ß-cells for normal Ca²? dynamics and insulin secretion..  Cell Calcium,  59  (32-40).  [PMID:26769314]
39. Sassano MF et al..  (2017)  Tobacco Smoke Constituents Trigger Cytoplasmic Calcium Release..  Appl In Vitro Toxicol,  (2): (193-198).  [PMID:28620626]
40. Conklin DJ et al..  (2019)  TRPA1 channel contributes to myocardial ischemia-reperfusion injury..  Am J Physiol Heart Circ Physiol,  316  (4): (H889-H899).  [PMID:30735434]
41. Liu L et al..  (2019)  TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling..  J Exp Clin Cancer Res,  38  (106).  [PMID:30819230]
42. Sreedhar A et al..  (2017)  UCP2 upregulation promotes PLC?-1 signaling during skin cell transformation..  Mol Carcinog,  56  (10): (2290-2300).  [PMID:28574619]
43. Ingelfinger R et al..  (2020)  Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach..  Front Pharmacol,  11  (1322).  [PMID:33013369]

Solution Calculators