FABP-IN-1 (Compounds 4b) is a high affinity fatty acid binding protein (FABP) inhibitor. FABP-IN-1 inhibits FABP3 , FABP5 , and FABP7 with K i values of 0.69 μM, 0.55 μM and 0.67 μM, respectively. FABP-IN-1 displays potent antinociceptive effects
In Vivo
FABP-IN-1 (Compounds 4b; 20 mg/kg; intraperitoneal injection; for 90 minutes; male wild-type C57BL/6 mice) treatment displays potent antinociceptive effects in CFA model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male wild-type C57BL/6 mice injected with complete Freund’s adjuvant (CFA) Dosage: 20 mg/kg Administration: Intraperitoneal injection; for 90 minutes Result: Displayed potent antinociceptive effects in CFA model.