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Fadrozole (CGS16949A) - 98%, high purity , CAS No.102676-47-1, Inhibitor of CYP11B1;Inhibitor of CYP11B2;Inhibitor of CYP19A1

  • Moligand™
  • ≥98%
Item Number
F414418
Grouped product items
SKUSizeAvailabilityPrice Qty
F414418-5mg
5mg
In stock
$42.90
F414418-10mg
10mg
In stock
$64.90
F414418-25mg
25mg
In stock
$123.90
F414418-50mg
50mg
In stock
$219.90
F414418-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$379.90
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Aromatase Inhibitors

View related series
CYP11B1 Inhibitor CYP11B2 Inhibitor CYP19A1 Inhibitor

Basic Description

SynonymsFADROZOLE|102676-47-1|4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile|CGS-16949A|Fadrozole [INN]|Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-|CHEMBL9298|FAD 286A|Fadrozole (INN)|H3988M64PU|4-{5H,6H,7H,8H-imidazo[1,5-a]pyrid
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsFadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of CYP11B1;Inhibitor of CYP11B2;Inhibitor of CYP19A1
Product Description

Information

Fadrozole (CGS16949A) Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.


Targets

Aromatase 4.5 nM

Product Properties

ALogP2.271
Rotatable Bond1

Names and Identifiers

IUPAC Name 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
INCHI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
InChi Key CLPFFLWZZBQMAO-UHFFFAOYSA-N
Canonical SMILES C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N
Isomeric SMILES C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N
PubChem CID 59693
Molecular Weight 223.27

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot NumberCertificate TypeDateItem
D2410448Certificate of AnalysisMar 23, 2024 F414418
D2410450Certificate of AnalysisMar 23, 2024 F414418
D2410451Certificate of AnalysisMar 23, 2024 F414418
D2410452Certificate of AnalysisMar 23, 2024 F414418
C2411008Certificate of AnalysisJul 05, 2022 F414418
K2212545Certificate of AnalysisJul 05, 2022 F414418
K2212546Certificate of AnalysisJul 05, 2022 F414418
K2212594Certificate of AnalysisJul 05, 2022 F414418
K2212599Certificate of AnalysisJul 05, 2022 F414418
K2212601Certificate of AnalysisJul 05, 2022 F414418

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 45 mg/mL (201.54 mM); Ethanol: 45 mg/mL (201.54 mM); Water: Insoluble;
SensitivityHygroscopic
DMSO(mg / mL) Max Solubility45
DMSO(mM) Max Solubility201.549693196578
Water(mg / mL) Max Solubility＜1

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Fadrozole (CGS16949A) - 10mM in DMSO, used for , CAS No. 102676-47-1, by Aladdin Scientific
    Fadrozole (CGS16949A)

    Starting at $143.90

References

1. Raats JI, Falkson G, Falkson HC.  (1992)  A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer..  J Clin Oncol,  10  (1): (111-6).  [PMID:1530798]
2. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A.  (1991)  Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease..  J Med Chem,  34  (2): (725-36).  [PMID:1825337]
3. LaSala D, Shibanaka Y, Jeng AY.  (2009)  Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors..  Anal Biochem,  394  (1): (56-61).  [PMID:19622340]

Solution Calculators

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