FAPI-4 - 98%, high purity , CAS No.2374782-02-0

Item Number

F648286

Grouped product items
SKU	Size	Availability	Price
F648286-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$780.90
F648286-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,250.90
F648286-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,550.90
F648286-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,950.90

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Basic Description

Synonyms	MS-31619 \| FAPI-04 \| FAPI-4 \| ICWDAESAANBIGG-LJAQVGFWSA-N \| AT39479 \| DOTA-fapi-04 \| EX-A5967 \| 2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl
Specifications & Purity	98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	FAPI-4 is a potent fibroblast activation protein ( FAP ) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68 Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer , with good tumor-to-background contrast ratios In Vivo FAPI-4 (Intravenous injection; 30 nmol per mouse; once) shows excellent tumor uptake in BALB/c nu / nu mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-week-old BALB/c nu / nu mice inoculated with HT-1080-FAP cellsDosage: 30 nmol per mouse Administration: Intravenous injection; 30 nmol per mouse; once Result: Revealed the high overall tumor uptake (9.44%ID/g 4 h after injection). Form:Solid IC50& Target:Fibroblast activation protein (FAP)

Names and Identifiers

IUPAC Name	2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
INCHI	InChI=1S/C40H54F2N10O10/c41-40(42)21-29(22-43)52(28-40)34(53)23-45-39(61)31-4-5-44-33-3-2-30(20-32(31)33)62-19-1-6-46-15-17-51(18-16-46)35(54)24-47-7-9-48(25-36(55)56)11-13-50(27-38(59)60)14-12-49(10-8-47)26-37(57)58/h2-5,20,29H,1,6-19,21,23-28H2,(H,45,61)(H,55,56)(H,57,58)(H,59,60)/t29-/m0/s1
InChi Key	ICWDAESAANBIGG-LJAQVGFWSA-N
Canonical SMILES	C1CN(CCN1CCCOC2=CC3=C(C=CN=C3C=C2)C(=O)NCC(=O)N4CC(CC4C#N)(F)F)C(=O)CN5CCN(CCN(CCN(CC5)CC(=O)O)CC(=O)O)CC(=O)O
Isomeric SMILES	C1CN(CCN1CCCOC2=CC3=C(C=CN=C3C=C2)C(=O)NCC(=O)N4CC(C[C@H]4C#N)(F)F)C(=O)CN5CCN(CCN(CCN(CC5)CC(=O)O)CC(=O)O)CC(=O)O
Alternate CAS	2374782-02-0
PubChem CID	138454803
MeSH Entry Terms	68Ga-FAPI;68Ga-FAPI-04;FAPI-04
Molecular Weight	872.91

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Basic Description