Standardised activity types and units

The following table stores details of standardised activity types and units, with permitted value ranges. Used to determine the correct standard type and standard units for a range of published types/units.

std_act_id	standard_type	definition	standard_units	normal_range_min	normal_range_max
1	CC50	Concentration required for 50% cytotoxicity	nM	1	10000000
2	EC50	Effective concentration for 50% activity	nM	0.01	100000
3	GI50	Concentration required for 50% growth inhibition	nM	1	10000000
4	IC50	Concentration required for 50% inhibition	nM	0.01	100000
5	Ki	Inhibition constant	nM	0.01	100000
6	Solubility	Solubility	nM	100	1000000000
7	Solubility	Solubility	ug.mL-1	0.05	50000
8	T1/2	Half-life	hr	0.001	10000
9	CL	Clearance	mL.min-1.g-1	0	10000
10	CL	Clearance	mL.min-1.kg-1	0	10000
11	CL_renal	Renal clearance	mL.min-1.kg-1	0	10000
12	CL/F	Clearance/Bioavailability	mL.min-1.kg-1	0	10000
13	CLogD	Calculated Log(Distribution Coefficient)	-	-10	15
14	CLogD7.4	Calculated Log(Distribution Coefficient) at pH7.4	-	-10	15
15	CLogP	Calculated Log(Partition Coefficient)	-	-10	15
16	F	Bioavailability	%	0	150
17	IC95	Concentration required for 95% inhibition	nM	0.01	100000
18	IFI	Inhibition Frequency (promiscuity) Index	%	0	100
19	Inhibition	Inhibition	%	-10	150
20	LogP	Log(Partition Coefficient)	-	-10	15
21	LogPapp	Log(Apparent permeability)	-	-10	15
22	Tmax	Time for maximum concentration	hr	0.01	1000
23	Vd	Volume of Distribution	L.kg-1	0.01	1000
24	Vdss	Steady State Volume of Distribution	L.kg-1	0.01	1000
25	XC50	Concentration required for 50% effect	nM	0.01	100000
26	Vd/F	Volume of distribution after non-intravenous administration	L.kg-1	0.01	1000
27	Cmax	Maximum concentration	ug.mL-1	0.0005	5000
28	Cmax	Maximum concentration	nM	1	10000000
29	IC50	Concentration required for 50% inhibition	ug.mL-1	0.000005	50
30	MRT	Mean residence time	hr	0.01	1000
31	IC90	Concentration required for 90% inhibition	nM	0.01	100000
32	IC90	Concentration required for 90% inhibition	ug.mL-1	0.000005	50
33	MCC	Minimum cytotoxic concentration	nM	1	10000000
34	MCC	Minimum cytotoxic concentration	ug.mL-1	0.0005	5000
35	MIC	Minimum inhibitory concentration	nM	1	10000000
36	MIC	Minimum inhibitory concentration	ug.mL-1	0.0005	5000
37	Kd	Dissociation constant	nM	0.01	100000
38	Vdss/F	Volume of distribution at steady state after non-intravenous administration	L.kg-1	0.01	1000
39	CC50	Concentration required for 50% cytotoxicity	ug.mL-1	0.0005	5000
40	EC50	Effective concentration for 50% activity	ug.mL-1	0.000005	50
41	GI50	Concentration required for 50% growth inhibition	ug.mL-1	0.0005	5000
42	IC99	Concentration required for 99% inhibition	nM	0.01	100000
43	IC99	Concentration required for 99% inhibition	ug.mL-1	0.000005	50
44	LC50	Concentration required for 50% lethality	nM	1	10000000
45	LC50	Concentration required for 50% lethality	ug.mL-1	0.0005	5000
46	TGI	Concentration required for total growth inhibition	nM	1	10000000
47	TGI	Concentration required for total growth inhibition	ug.mL-1	0.0005	5000
48	LD50	Dose required for 50% lethality	mg.kg-1	0.0005	5000
49	LD50	Dose required for 50% lethality	umol.kg-1	0.001	10000
50	Km	Michaelis constant	nM	10	100000000
51	Potency	Concentration or dose required to elicit a specific response	nM	1	10000000
52	AC50	Concentration required for 50% activity	nM	0.01	100000
53	ED50	Effective dose for 50% activity	mg.kg-1	0.0005	500
54	IZ	Zone of inhibition	mm	0	50
55	MIC50	Minimum inhibitory concentration in 50% of population	nM	1	10000000
56	MIC80	Minimum inhibitory concentration in 80% of population	nM	1	10000000
57	MIC90	Minimum inhibitory concentration in 90% of population	nM	1	10000000
58	MIC50	Minimum inhibitory concentration in 50% of population	ug.mL-1	0.0005	5000
59	MIC80	Minimum inhibitory concentration in 80% of population	ug.mL-1	0.0005	5000
60	MIC90	Minimum inhibitory concentration in 90% of population	ug.mL-1	0.0005	5000
61	MIC70	Minimum inhibitory concentration in 70% of population	ug.mL-1	0.0005	5000
62	ID50	Dose required for 50% inhibition	mg.kg-1	0.0005	500
63	ID50	Dose required for 50% inhibition	umol.kg-1	0.001	1000
64	ED50	Effective dose for 50% activity	umol.kg-1	0.001	1000
65	k_obs	Observed rate constant	s-1	0.000001	100000
66	k_on	Association rate constant	M-1.s-1	1	10000000
67	k_off	Dissociation rate constant	s-1	0.000001	1000
68	CK	A measurement of the total creatine kinase in a biological specimen.	U.L-1
69	PT	A blood clotting measurement that evaluates the extrinsic pathway of coagulation.	s
70	ALB	A measurement of the albumin protein in a biological specimen.	ug.mL-1
71	ALP	A measurement of the alkaline phosphatase in a biological specimen.	U.L-1
72	ALP	A measurement of the alkaline phosphatase in a biological specimen.	IU.L-1
73	ALT	A measurement of the alanine aminotransferase in a biological specimen.	U.L-1
74	ALT	A measurement of the alanine aminotransferase in a biological specimen.	IU.L-1
75	AST	A measurement of the aspartate aminotransferase in a biological specimen.	U.L-1
76	AST	A measurement of the aspartate aminotransferase in a biological specimen.	IU.L-1
77	BUN	A measurement of the urea nitrogen in a blood specimen.	ug.mL-1
78	CO2	A measurement of the carbon dioxide gas in a biological specimen.	nM
79	EOS	A measurement of the eosinophils in a biological specimen.	cells.uL-1
80	GGT	A measurement of the gamma glutamyl transferase in a biological specimen.	IU.L-1
81	HCT	The percentage of a whole blood specimen that is composed of red blood cells (erythrocytes).	%
82	HGB	A measurement of the hemoglobin in a biological specimen.	ug.mL-1
83	LDH	A measurement of the lactate dehydrogenase in a biological specimen.	U.L-1
84	LDH	A measurement of the lactate dehydrogenase in a biological specimen.	IU.L-1
85	LYM	A measurement of the lymphocytes in a biological specimen.	cells.uL-1
86	MCH	A quantitative measurement of the mean amount of hemoglobin per erythrocyte in a biological specimen.	pg
87	MCV	A quantitative measurement of the mean volume of erythrocytes in a biological specimen.	fL
88	RBC	A measurement of the total erythrocytes in a biological specimen.	cells.uL-1
89	WBC	A measurement of the leukocytes in a biological specimen.	cells.uL-1
90	APTT	A measurement of the length of time that it takes for clotting to occur when reagents are added to a plasma specimen. The test is partial due to the absence of tissue factor (Factor III) from the reaction mixture.	s
91	BASO	A measurement of the basophils in a biological specimen.	cells.uL-1
92	BILI	A measurement of the total bilirubin in a biological specimen.	ug.mL-1
93	CHOL	A measurement of the cholesterol in a biological specimen.	ug.mL-1
94	GLUC	A measurement of the glucose in a biological specimen.	ug.mL-1
95	MCHC	A quantitative measurement of the mean amount of hemoglobin per erythrocytes in a specified volume of a biological specimen.	%
96	MCHC	A quantitative measurement of the mean amount of hemoglobin per erythrocytes in a specified volume of a biological specimen.	ug.mL-1
97	MONO	A measurement of the monocytes in a biological specimen.	cells.uL-1
98	PHOS	A measurement of the phosphate in a biological specimen.	ug.mL-1
99	PLAT	A measurement of the platelets (non-nucleated thrombocytes) in a biological specimen.	cells.uL-1
100	PROT	A measurement of a group of complex organic macromolecules composed of one or more alpha-L-amino acid chains in a biological specimen.	ug.mL-1
101	TRIG	A measurement of the triglycerides in a biological specimen.	ug.mL-1
102	CREAT	A measurement of the creatinine in a biological specimen.	ug.mL-1
103	EOSLE	A relative measurement (ratio or percentage) of the eosinophils to leukocytes in a biological specimen.	%
104	LYMLE	A relative measurement (ratio or percentage) of the lymphocytes to leukocytes in a biological specimen.	%
105	URATE	A measurement of the urate in a biological specimen.	ug.mL-1
106	BASOLE	A relative measurement (ratio or percentage) of the basophils to leukocytes in a biological specimen.	%
107	BILDIR	A measurement of the conjugated or water-soluble bilirubin in a biological specimen.	ug.mL-1
108	LIPASE	A measurement of the pancreatic lipase in a biological specimen.	U.L-1
109	MONOLE	A relative measurement (ratio or percentage) of the monocytes to leukocytes in a biological specimen.	%
110	NEUTLE	A relative measurement (ratio or percentage) of the neutrophils to leukocytes in a biological specimen.	%
111	NEUTSG	A measurement of the segmented neutrophils in a biological specimen.	cells.uL-1
112	RBCNUC	A measurement of the nucleated erythrocytes (large, immature nucleated erythrocytes) in a biological specimen.	/100WBC
113	SODIUM	A measurement of the sodium in a biological specimen.	mEq.L-1
114	TERMBW	The weight of a subject at a specified end point. (NCI)	g
115	WEIGHT	The vertical force exerted by a mass as a result of gravity. (NCI)	g
116	ALBGLOB	The ratio of albumin to globulin in a biological specimen.	-
117	CALCIUM	A measurement of the calcium in a biological specimen.	ug.mL-1
118	FIBRINO	A measurement of the fibrinogen in a biological specimen.	ug.mL-1
119	PHOSLPD	A measurement of the phospholipids in a biological specimen.	ug.mL-1
120	RETIRBC	A relative measurement (ratio or percentage) of reticulocytes to erythrocytes in a biological specimen.	%
121	CHLORIDE	A measurement of the chloride in a biological specimen.	mEq.L-1
122	POTASSIUM	A measurement of the potassium in a biological specimen.	mEq.L-1
124	AUC	Area under the drug concentration time curve	uM.hr	0.001	10000
127	AUC	Area under the drug concentration time curve	ng.hr.mL-1	10	10000000
130	fAUC	Area under the free drug concentration time curve	uM.hr	0.001	10000
134	fAUC	Area under the free drug concentration time curve	ng.hr.mL-1	10	10000000
135	CL	Clearance	uL.min-1.(10^6cells)-1	0.1	500
136	Compound recovery	Recovery of a specific compound (e.g. parent or metabolite) in plasma, tissue or excreta, e.g. as absolute or qualitative measurement, percentage of dose recovered	ng.eq.g-1
137	Radiolabel recovery	Recovery of radioactivity in plasma, tissue or excreta after administration of radiolabelled compound, as absolute measurement or percentage of dose	ng.eq.g-1
138	Compound recovery	Recovery of a specific compound (e.g. parent or metabolite) in plasma, tissue or excreta, e.g. as absolute or qualitative measurement, percentage of dose recovered	ng.eq.mL-1
139	Radiolabel recovery	Recovery of radioactivity in plasma, tissue or excreta after administration of radiolabelled compound, as absolute measurement or percentage of dose	ng.eq.mL-1
140	Compound recovery	Recovery of a specific compound (e.g. parent or metabolite) in plasma, tissue or excreta, e.g. as absolute or qualitative measurement, or percentage of dose recovered	%
141	Radiolabel recovery	Recovery of radioactivity in plasma, tissue or excreta after administration of radiolabelled compound, as absolute measurement or percentage of dose	%
142	AUC	Area under the drug concentration time curve	ng.hr.g-1
143	Cmax	Maximum concentration	ug.g-1
144	Log S	Log of solubility	-
145	Kb	Equilibrium binding constant	nM	0.01	100000
146	LogD	Log(Distribution Coefficient)	-	-10	15
147	LogD7.4	Log(Distribution Coefficient) at pH 7.4	-	-10	15
148	Delta Tm	Change in melting temperature	degrees C
149	Fu	Fraction of compound unbound	-	0	1
150	PPB	Plasma protein binding as %bound	%	0	105
152	DOSE	Amount of a substance administered	mg.kg-1
153	TIME	Point at which an experimental intervention is performed e.g., dosing of a substance, measuring a sample	hr
154	LogD5.0	Log(Distribution Coefficient) at pH 5.0	-	-10	15
155	LogD6.5	Log(Distribution Coefficient) at pH 6.5	-	-10	15
156	LogD5.5	Log(Distribution Coefficient) at pH 5.5	-	-10	15
159	APDc	Normalised action potential duration (APD) defined as: APD (ms) / cube root of Beat Interval (ms)	-
160	FPDc	Normalised field potential duration (FPD) defined as: FPD (ms) / cube root of Beat Interval (ms)	-
161	Stability	A measurement of the chemical or metabolic stability of the compound.	%

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