DEAE-Dextran

Aladdin DEAE-Dextran are based on Aladdin Dextran

Aladdin DEAE-Dextran are based on Aladdin’ world-leading Dextran products, and Aladdin DEAE-Dextran are also produced at the state-of-the-art, GMP-approved facility

As a natural consequence of Aladdin’ commitment to quality, Aladdin DEAE-Dextran are developed and manufactured according to the same advanced standards and requirements of the highest quality as applied in the development and manufacturing of our world-leading Dextran products.

DEAE-Dextran

DEAE-Dextran is made by reaction of dextran with (2-chloroethyl) diethylammoniumchlorid in alkaline solution.

Fig. 1: DEAE-Dextran 

DEAE-Dextran is a polycation. DEAE - Dextran contains three basic groups with different pKa values. There are two tertiary groups, one in the single substituted glucose unit having a pKa value of approximately 9.2 and the tertiary group in the tandem substitution having a pKa value of approximately 5.5. The quaternary amino group in the tandem substitution has a pKa value ~ 14.

Below in Fig.2 is shown the titration curve from titration of DEAE - Dextran after alkanation.