Fasinumab (anti-NGF) - Primary antibody, specific to NGF, Human IgG4SP, INHIBITOR of Beta-nerve growth factor inhibitor

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Human IgG4SP

Application:

Item Number

Ab175536

Grouped product items
SKU	Size	Availability	Price
Ab175536-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$39.90
Ab175536-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$169.90
Ab175536-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$509.90
Ab175536-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$859.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

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Basic Description

Product Name	Fasinumab (anti-NGF) - Primary antibody, specific to NGF, Human IgG4SP
Synonyms	REGN475;SAR164877
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	NGF
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	INHIBITOR of Beta-nerve growth factor inhibitor
Product Description	Fasinumab (anti-NGF) is a human IgG1k monoclonal antibody to nerve growth factor (NGF). Fasinumab (anti-NGF) can be used in acute sciatica and knee osteoarthritis (OA) studies. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Isotype	Human IgG4SP
Light Chain Type	kappa
SDS-PAGE	145 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	1190239-42-9

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0404816	Certificate of Analysis	Apr 23, 2024	Ab175536
ZJ24F0404815	Certificate of Analysis	Apr 23, 2024	Ab175536
ZJ24F0404814	Certificate of Analysis	Apr 23, 2024	Ab175536

References

1. Hefti FF, Rosenthal A, Walicke PA, Wyatt S, Vergara G, Shelton DL, Davies AM. (2006) Novel class of pain drugs based on antagonism of NGF.. Trends Pharmacol Sci, 27 (2): (85-91). [PMID:16376998]
2. Hill R. (2011) Blocking the effects of NGF as a route to safe and effective pain relief--fact or fancy?. Pain, 152 (10): (2200-1). [PMID:21719197]
3. Leite VF, Buehler AM, El Abd O, Benyamin RM, Pimentel DC, Chen J, Hsing WT, Mazloomdoost D, Amadera JE. (2014) Anti-nerve growth factor in the treatment of low back pain and radiculopathy: a systematic review and a meta-analysis.. Pain Physician, 17 (1): (E45-60). [PMID:24452657]
4. Tiseo PJ, Ren H, Mellis S. (2014) Fasinumab (REGN475), an antinerve growth factor monoclonal antibody, for the treatment of acute sciatic pain: results of a proof-of-concept study.. J Pain Res, 7 (3): (523-30). [PMID:25210473]

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Basic Description