Fenbendazole-d 3 is a deuterium labeled Fenbendazole. Fenbendazole-d 3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.
In Vitro
Fenbendazole-d3 (20 µM; for 48 h) reverses the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration. Fenbendazole-d3 (10 µM; for 48 h) elevates the protein expression levels of HIF-1α and GLUT1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: BT-549 and MCF-7 cells Concentration: 20 µM Incubation Time: For 48 h Result: Reversed the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration. Western Blot AnalysisCell Line: BT-549 and MCF-7 cells Concentration: 10 µM Incubation Time: For 48 h Result: Elevated the protein expression levels of HIF-1α and GLUT1.
