Fenbendazole-d3 - 99%, high purity , CAS No.1228182-47-5

  • ≥99%
Item Number
F647881
Grouped product items
SKUSizeAvailabilityPrice Qty
F647881-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$70.90
F647881-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$140.90
F647881-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$230.90

Basic Description

SynonymsFenbendazole-d3, VETRANAL(TM), analytical standard | Fenbendazole D3 (methyl D3) 100 microg/mL in Acetonitrile | F90888 | Fenbendazole-d3 | Trideuteriomethyl N-(5-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate; Trideuteriomethyl N-(6-phenylsulfanyl-1H-benz
Specifications & Purity≥99%
Biochemical and Physiological MechanismsFenbendazole-d 3 is a deuterium labeled Fenbendazole. Fenbendazole-d 3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is
Storage TempProtected from light,Store at -80°C
Shipped InIce chest + Ice pads
Product Description

Fenbendazole-d 3 is a deuterium labeled Fenbendazole. Fenbendazole-d 3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.

In Vitro

Fenbendazole-d3 (20 µM; for 48 h) reverses the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration. Fenbendazole-d3 (10 µM; for 48 h) elevates the protein expression levels of HIF-1α and GLUT1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: BT-549 and MCF-7 cells Concentration: 20 µM Incubation Time: For 48 h Result: Reversed the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration. Western Blot AnalysisCell Line: BT-549 and MCF-7 cells Concentration: 10 µM Incubation Time: For 48 h Result: Elevated the protein expression levels of HIF-1α and GLUT1.

Form:Solid

Names and Identifiers

IUPAC Name trideuteriomethyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate
INCHI InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)/i1D3
InChi Key HDDSHPAODJUKPD-FIBGUPNXSA-N
Canonical SMILES COC(=O)NC1=NC2=C(N1)C=C(C=C2)SC3=CC=CC=C3
Isomeric SMILES [2H]C([2H])([2H])OC(=O)NC1=NC2=C(N1)C=C(C=C2)SC3=CC=CC=C3
Alternate CAS 1228182-47-5
PubChem CID 71312505
Molecular Weight 302.37

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Chemical and Physical Properties

SolubilityDMSO : 5 mg/mL (16.54 mM; ultrasonic and warming and heat to 60°C)

Related Documents

Solution Calculators