| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| F408509-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $59.90 |
Ferroptosis Inhibitors
| Synonyms | Ethyl 3-Amino-4-(cyclohexylamino)benzoate；3-Amino-4-cyclohexylaminobenzoic Acid Ethyl Ester；Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Argon charged,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions. In vivo
cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| Canonical SMILES | CCOC(=O)C1=CC=C(NC2CCCCC2)C(=C1)N |
|---|---|
| Molecular Weight | 262.35 |
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| Sensitivity | Sensitive to light; sensitive to heating; |
|---|
| 1. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2024) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 265 (116110). [PMID:38194774] |
| 2. Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou. (2023) Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis. CHEMICO-BIOLOGICAL INTERACTIONS, 384 (18): (110713). [PMID:37716422] |
| 3. Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan. (2023) Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis. Phytochemistry Letters, 55 (80). [PMID:] |
| 4. Wenhua Wang, Wenhao Wang, Shiwei Jin, Fangqin Fu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan. (2023) Open pocket and tighten holes: Inhalable lung cancer-targeted nanocomposite for enhanced ferroptosis-apoptosis synergetic therapy. CHEMICAL ENGINEERING JOURNAL, 458 (141487). [PMID:] |
| 5. Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo, Tian Lan. (2023) Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation. Food & Function, 14 (4): (1884-1896). [PMID:36723004] |
| 6. Mingbo Wu, Wenwu Ling, Jiaojun Wei, Ran Liao, Haiyue Sun, Dongqiu Li, Ye Zhao, Long Zhao. (2022) Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment. JOURNAL OF CONTROLLED RELEASE, 352 (1116). [PMID:36402233] |
| 7. Huan Huang, Yuling Chen, Na Yin, Gaojie Li, Shanshan Ye, Ling Guo, Min Feng. (2023) Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy. MOLECULAR PHARMACEUTICS, 20 (1): (290–302). [PMID:36368878] |
| 8. Li Xie, Wenjie Chen, Qifang Chen, Yang Jiang, Erqun Song, Xiaokang Zhu, Yang Song. (2022) Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory. Materials Today Bio, 16 (100353). [PMID:35865409] |
| 9. Shuwei Qiao, Baosheng Li, Qing Cai, Zhen Li, Zhaoyi Yin, Jie He, Yuyang Li, Weiyan Meng. (2022) Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide-stimulated periodontitis in vitro and in vivo. ORAL DISEASES, [PMID:35765229] |
| 10. Hao Chi, Guang Zhu, Yalin Yin, He Diao, Zicheng Liu, Shibo Sun, Zhaoming Guo, Weiping Xu, Jianqiang Xu, Changhao Cui, Xiao-Jin Xing, Kun Ma. (2022) Dual-Responsive multifunctional “core–shell” magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 622 (121898). [PMID:35688287] |
| 11. Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang. (2023) Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance. Bioactive Materials, 19 (1). [PMID:35415315] |
| 1. Xiaosi Lin , Le Dong, Qing Miao, Zhaobin Huang, Fang Wang. (2024) Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small cell lung cancer cell lines. European Journal of Pharmacology, 无 (974): (176608). [PMID:38663542] |
| 2. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2024) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 265 (116110). [PMID:38194774] |
| 3. Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou. (2023) Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis. CHEMICO-BIOLOGICAL INTERACTIONS, 384 (18): (110713). [PMID:37716422] |
| 4. Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan. (2023) Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis. Phytochemistry Letters, 55 (80). [PMID:] |
| 5. Wenhua Wang, Wenhao Wang, Shiwei Jin, Fangqin Fu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan. (2023) Open pocket and tighten holes: Inhalable lung cancer-targeted nanocomposite for enhanced ferroptosis-apoptosis synergetic therapy. CHEMICAL ENGINEERING JOURNAL, 458 (141487). [PMID:] |
| 6. Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo, Tian Lan. (2023) Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation. Food & Function, 14 (4): (1884-1896). [PMID:36723004] |
| 7. Mingbo Wu, Wenwu Ling, Jiaojun Wei, Ran Liao, Haiyue Sun, Dongqiu Li, Ye Zhao, Long Zhao. (2022) Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment. JOURNAL OF CONTROLLED RELEASE, 352 (1116). [PMID:36402233] |
| 8. Huan Huang, Yuling Chen, Na Yin, Gaojie Li, Shanshan Ye, Ling Guo, Min Feng. (2023) Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy. MOLECULAR PHARMACEUTICS, 20 (1): (290–302). [PMID:36368878] |
| 9. Li Xie, Wenjie Chen, Qifang Chen, Yang Jiang, Erqun Song, Xiaokang Zhu, Yang Song. (2022) Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory. Materials Today Bio, 16 (100353). [PMID:35865409] |
| 10. Shuwei Qiao, Baosheng Li, Qing Cai, Zhen Li, Zhaoyi Yin, Jie He, Yuyang Li, Weiyan Meng. (2022) Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide-stimulated periodontitis in vitro and in vivo. ORAL DISEASES, [PMID:35765229] |
| 11. Hao Chi, Guang Zhu, Yalin Yin, He Diao, Zicheng Liu, Shibo Sun, Zhaoming Guo, Weiping Xu, Jianqiang Xu, Changhao Cui, Xiao-Jin Xing, Kun Ma. (2022) Dual-Responsive multifunctional “core–shell” magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 622 (121898). [PMID:35688287] |
| 12. Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang. (2023) Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance. Bioactive Materials, 19 (1). [PMID:35415315] |
