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Fexaramine - ≥97%(HPLC), high purity , CAS No.574013-66-4, Agonist of Farnesoid X receptor
Potent and selective farnesoid X receptor (FXR) agonist
Basic Description Synonyms Fexaramine|574013-66-4|WTG9GFA65U|CHEMBL192966|CHEBI:80003|methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate|(E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamid Specifications & Purity Moligand™, ≥97%(HPLC) Biochemical and Physiological Mechanisms Fexaramine is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 25 nM. It has no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of Farnesoid X receptor
Names and Identifiers Pubchem Sid 488195366 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195366 IUPAC Name methyl (E)-3-[3-[cyclohexanecarbonyl-[[4-[4-(dimethylamino)phenyl]phenyl]methyl]amino]phenyl]prop-2-enoate INCHI InChI=1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1-3H3/b21-14+ InChi Key VLQTUNDJHLEFEQ-KGENOOAVSA-N Canonical SMILES CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)C=CC(=O)OC)C(=O)C4CCCCC4 Isomeric SMILES CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)/C=C/C(=O)OC)C(=O)C4CCCCC4 PubChem CID 5326713 Molecular Weight 496.64
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 49.66, Max Conc. mM: 100 Sensitivity Moisture sensitive
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