Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab170546-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
| Ab170546-1mg | 1mg | In stock | $267.90 | |
| Ab170546-5mg | 5mg | In stock | $627.90 | |
| Ab170546-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,017.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Fezakinumab (anti-IL-22), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL22, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | Cytokine Zcyto18 antibody; IL 10 related T cell derived inducible factor antibody; IL 21 antibody; IL 22 antibody; IL D110 antibody; IL TIF antibody; IL-10-related T-cell-derived-inducible factor antibody; IL-22 antibody; IL-TIF antibody; IL21 antibody; I |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | IL22 |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Interleukin-22 inhibitor |
| Product Description | Fezakinumab is an interleukin-22 (IL-22) monoclonal antibody. Fezakinumab can be used for the research of inflammatory disease, such as psoriasis and rheumatoid arthritis. Purity |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG1 |
| Light Chain Type | lambda C2 |
| SDS-PAGE | 28.1 kDa (Light Chain) & 53.8 kDa (Heavy Chain), under reducing conditions; 183.3 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1007106-86-6 |
Fezakinumab (anti-IL-22) (Ab170546) - ELISA
Immobilized Recombinant Human IL-22 Protein at 1 μg/mL can bind Fezakinumab (anti-IL-22) (Ab170546) with the EC₅₀ of 69.72 ng/mL.
Fezakinumab (anti-IL-22) (Ab170546) - SEC
The purity of Fezakinumab (anti-IL-22) (Ab170546) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| IMGT/mAb-DB | 323 |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F1101604 | Certificate of Analysis | Nov 08, 2023 | Ab170546 |
| ZJ23F1101605 | Certificate of Analysis | Nov 08, 2023 | Ab170546 |
| 1. Xie, M H MH and 8 more authors.. (2000) Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.. The Journal of biological chemistry, (6): [PMID:10875937] |
| 2. Dumoutier, L L, Van Roost, E E, Colau, D D and Renauld, J C JC.. (2000) Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.. Proceedings of the National Academy of Sciences of the United States of America, (29): [PMID:10954742] |
| 3. Dumoutier, L L, Van Roost, E E, Ameye, G G, Michaux, L L and Renauld, J C JC.. (2000) IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes.. Genes and immunity, [PMID:11197690] |
| 4. Nagem, R A P RA and 5 more authors.. (2002) Crystallization and synchrotron X-ray diffraction studies of human interleukin-22.. Acta crystallographica. Section D, Biological crystallography, [PMID:11856845] |
| 5. Brand, Stephan S and 14 more authors.. (2007) IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.. American journal of physiology. Gastrointestinal and liver physiology, [PMID:17204547] |
| 6. Jones, Brandi C BC, Logsdon, Naomi J NJ and Walter, Mark R MR.. (2008) Structure of IL-22 bound to its high-affinity IL-22R1 chain.. Structure (London, England : 1993), (10): [PMID:18599299] |
| 7. Akil, Hussein H and 12 more authors.. (2015) IL22/IL-22R pathway induces cell survival in human glioblastoma cells.. PloS one, [PMID:25793261] |
| 8. Moniruzzaman, Md M, Wang, Ran R, Jeet, Varinder V, McGuckin, Michael A MA and Hasnain, Sumaira Z SZ.. (2019) Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway.. International journal of molecular sciences, (15): [PMID:31311100] |
