| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| F407915-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $193.90 |
S1P Receptor Antagonists
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Fingolimod (FTY720) HCl Fingolimod (FTY720) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells. The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720. Medium and high-dose FTY720-P also enhances the levels of TGF-β1. TGF-β1 and Foxp3 mRNA expression are upregulated in the high-dose FTY720-P group. The proliferation of effector T cells is suppressed significantly in the medium and high-dose FTY720-P group at a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, the proliferation of effector T cells is also suppressed in the high-dose FTY720 group. In vivo FTY720 is effective in Ph+ but not Ph- ALL xenografts using an early disease model. FTY720 produces a significant reduction in disease burden in the Ph+ ALL xenografts using an early disease model. Ph+ human ALL xenografts responds to FTY720 with an 80 % reduction in overall disease if treatment has been initiated early on. In contrast, treatment of mice with FTY720 does not result in reduced leukemia compared to controls using four separate human Ph- ALL xenografts. cell lines：Abl-MLV, Rat 2, KU812, K562, and MEG-01 cells Concentrations：10 nM Incubation Time：4 hours Powder Purity:≥99% |
| Canonical SMILES | Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 |
|---|---|
| Molecular Weight | 343.9 |
Enter Lot Number to search for COA:
| Pictogram(s) | GHS08 |
|---|---|
| Signal | Warning |
| Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure |
| Precautionary Statements | P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P314:Get medical advice/attention if you feel unwell. |
