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FIPI - ≥98%, high purity , CAS No.939055-18-2, Inhibitor of PLD1;Inhibitor of PLD2

  • Moligand™
  • ≥98%
Item Number
F340883
Grouped product items
SKUSizeAvailabilityPrice Qty
F340883-1mg
1mg
In stock
$21.90
F340883-5mg
5mg
In stock
$90.90
F340883-10mg
10mg
In stock
$142.90
F340883-25mg
25mg
In stock
$321.90
F340883-50mg
50mg
In stock
$521.90
F340883-100mg
100mg
In stock
$848.90
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a cell-permeable, PLD1/2 inhibitor

View related series
PLD1 Inhibitor PLD2 Inhibitor

Basic Description

SynonymsFIPI|939055-18-2|FIPI free base|5-Fluoro-2-indolyl deschlorohalopemide|5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide|5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of PLD1;Inhibitor of PLD2
Product Description

FIPI is a cell-permeable, PC-PLD1/2 (PLD1/2) inhibitor (IC|50|= 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC|50|= 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. FIPI is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM.

Product Properties

pKapKa: 12.04 (Predicted), pKa: 8.53 (Predicted)

Associated Targets

PLD1 Tchem Phospholipase D1 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLD2 Tchem Phospholipase D2 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide
INCHI InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31)
InChi Key LHABRXRGDLASIH-UHFFFAOYSA-N
Canonical SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F
Isomeric SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F
PubChem CID 16739265
Molecular Weight 421.48

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
A2219605Certificate of AnalysisMay 26, 2022 F340883
G2219599Certificate of AnalysisMay 26, 2022 F340883
G2219600Certificate of AnalysisMay 26, 2022 F340883
G2219601Certificate of AnalysisMay 26, 2022 F340883
G2219602Certificate of AnalysisMay 26, 2022 F340883
G2219603Certificate of AnalysisMay 26, 2022 F340883

Chemical and Physical Properties

SolubilitySoluble in 1:9 DMF:PBS(ph7.2) (~0.1 mg/ml), ethanol (~0.25 mg/ml), DMSO (~20 mg/ml), and DMF (~20 mg/ml).
Refractive Indexn20D~1.66 (Predicted)
Melt Point(°C)295.54° C (Predicted)

Related Documents

 SDS

 Specification Sheet

References

1. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA.  (2009)  Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness..  Nat Chem Biol,  5  (2): (108-17).  [PMID:19136975]

Solution Calculators

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