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FITM - ≥98%(HPLC), high purity , CAS No.932737-65-0, Allosteric modulator of mGlu 1 receptor

  • Moligand™
  • ≥98%(HPLC)
Item Number
F288564
Grouped product items
SKUSizeAvailabilityPrice Qty
F288564-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
F288564-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$121.90
F288564-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$246.90
F288564-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90

Potent and selective negative allosteric modulator of mGlu1receptors

Basic Description

Synonyms4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsPotent and selective negative allosteric modulator of mGlu1receptors (IC50= 5.1 nM). Displays >1300-fold selectivity for mGlu1over other metabotropic glutamate receptors (IC50values are 7 μM and >10 μM for mGlu5and mGlu2or mGlu8, respectively). Antagonize
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of mGlu 1 receptor

Associated Targets

GRM1 Tchem Metabotropic glutamate receptor 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM2 Tchem Metabotropic glutamate receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM8 Tchem Metabotropic glutamate receptor 8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-fluoro-N-methyl-N-[4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]benzamide
INCHI InChI=1S/C18H18FN5OS/c1-11(2)22-16-8-14(20-10-21-16)15-9-26-18(23-15)24(3)17(25)12-4-6-13(19)7-5-12/h4-11H,1-3H3,(H,20,21,22)
InChi Key WIVGIKIKQHUFOD-UHFFFAOYSA-N
Canonical SMILES CC(C)NC1=NC=NC(=C1)C2=CSC(=N2)N(C)C(=O)C3=CC=C(C=C3)F
Isomeric SMILES CC(C)NC1=NC=NC(=C1)C2=CSC(=N2)N(C)C(=O)C3=CC=C(C=C3)F
PubChem CID 16660135
MeSH Entry Terms (18F)FITM;4-fluoro-ITM-benzamide;4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methylbenzamide
Molecular Weight 371.43

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
C2429562Certificate of AnalysisFeb 26, 2024 F288564
C2429563Certificate of AnalysisFeb 26, 2024 F288564
C2429564Certificate of AnalysisFeb 26, 2024 F288564
C2429565Certificate of AnalysisFeb 26, 2024 F288564
C2429566Certificate of AnalysisFeb 26, 2024 F288564
C2429567Certificate of AnalysisFeb 26, 2024 F288564
C2429568Certificate of AnalysisFeb 26, 2024 F288564
C2429569Certificate of AnalysisFeb 26, 2024 F288564

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 37.14, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.43, Max Conc. mM: 20

Related Documents

References

1. Fujinaga M, Yamasaki T, Yui J, Hatori A, Xie L, Kawamura K, Asagawa C, Kumata K, Yoshida Y, Ogawa M et al..  (2012)  Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain..  J Med Chem,  55  (5): (2342-52).  [PMID:22316010]

Solution Calculators