Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
F288564-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
F288564-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $121.90 | |
F288564-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $246.90 | |
F288564-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $399.90 |
Potent and selective negative allosteric modulator of mGlu1receptors
Synonyms | 4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide |
---|---|
Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent and selective negative allosteric modulator of mGlu1receptors (IC50= 5.1 nM). Displays >1300-fold selectivity for mGlu1over other metabotropic glutamate receptors (IC50values are 7 μM and >10 μM for mGlu5and mGlu2or mGlu8, respectively). Antagonize |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of mGlu 1 receptor |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | 4-fluoro-N-methyl-N-[4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]benzamide |
---|---|
INCHI | InChI=1S/C18H18FN5OS/c1-11(2)22-16-8-14(20-10-21-16)15-9-26-18(23-15)24(3)17(25)12-4-6-13(19)7-5-12/h4-11H,1-3H3,(H,20,21,22) |
InChi Key | WIVGIKIKQHUFOD-UHFFFAOYSA-N |
Canonical SMILES | CC(C)NC1=NC=NC(=C1)C2=CSC(=N2)N(C)C(=O)C3=CC=C(C=C3)F |
Isomeric SMILES | CC(C)NC1=NC=NC(=C1)C2=CSC(=N2)N(C)C(=O)C3=CC=C(C=C3)F |
PubChem CID | 16660135 |
MeSH Entry Terms | (18F)FITM;4-fluoro-ITM-benzamide;4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methylbenzamide |
Molecular Weight | 371.43 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C2429562 | Certificate of Analysis | Feb 26, 2024 | F288564 |
C2429563 | Certificate of Analysis | Feb 26, 2024 | F288564 |
C2429564 | Certificate of Analysis | Feb 26, 2024 | F288564 |
C2429565 | Certificate of Analysis | Feb 26, 2024 | F288564 |
C2429566 | Certificate of Analysis | Feb 26, 2024 | F288564 |
C2429567 | Certificate of Analysis | Feb 26, 2024 | F288564 |
C2429568 | Certificate of Analysis | Feb 26, 2024 | F288564 |
C2429569 | Certificate of Analysis | Feb 26, 2024 | F288564 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 37.14, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.43, Max Conc. mM: 20 |
---|
1. Fujinaga M, Yamasaki T, Yui J, Hatori A, Xie L, Kawamura K, Asagawa C, Kumata K, Yoshida Y, Ogawa M et al.. (2012) Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain.. J Med Chem, 55 (5): (2342-52). [PMID:22316010] |